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Title: Alpha-Blocker Prescribing Trends for Ureteral Stones: A Single-Centre Study.
Austin Authors: Qu, Liang G ;Chan, Garson ;Gani, Johan 
Affiliation: Urology
Department of Surgery, Division of Urology, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Urology, Western Health, Footscray, Victoria, Australia
Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 2022
Date: 2022
Publication information: Research and Reports in Urology 2022; 14: 297-303
Abstract: Recommendations for alpha-blockers have shifted in the conservative management of ureteral stones. It is unknown whether real-life practices regarding alpha-blocker prescriptions reflect updates in evidence. This study aimed to characterise alpha-blocker prescriptions for conservatively managed ureteral stones and relate this to recent literature. This was a retrospective audit, 01/01/2014 to 01/01/2019, of emergency acute renal colic presentations. Patients were included if they had a confirmed ureteral stone and were conservatively managed. The rates of alpha-blocker prescriptions were analysed using interrupted time-series analyses. May 2015 was selected as the cut-point to analyse before and after trend lines. Results were stratified by stone size and location. Tamsulosin and prazosin prescriptions were also compared. This study included 2163 presentations: 70.4% were stones ≤5 mm and 61.4% were proximal stones. Altogether, 24.7% of presentations were prescribed alpha-blockers. There was a fall in alpha-blocker prescription rates from before to after May 2015, regardless of stone size or location (p < 0.001). Since May 2015, however, there was a monthly rate increase of 0.5% for patients with stones >5mm. This study demonstrated a significant shift in rates of alpha-blocker prescriptions, possibly related to the influence of updates in available high-quality evidence.
DOI: 10.2147/RRU.S372208
ORCID: 0000-0002-5710-1983
Journal: Research and Reports in Urology
PubMed URL: 36060307
ISSN: 2253-2447
Type: Journal Article
Subjects: adrenergic alpha-antagonists
emergency medicine
renal colic
ureteric calculus
Appears in Collections:Journal articles

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