Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30820
Title: Compulsive-like eating of high-fat high-sugar food is associated with 'addiction-like' glutamatergic dysfunction in obesity prone rats.
Austin Authors: Sketriene, Diana;Battista, Damien;Lalert, Laddawan;Kraiwattanapirom, Natcharee;Thai, Han Ngoc;Leeboonngam, Tanawan;Knackstedt, Lori A;Nithianantharajah, Jess;Sumithran, Priya ;Lawrence, Andrew J;Brown, Robyn M
Affiliation: Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand..
The Florey Institute of Neuroscience and Mental Health
The Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Australia..
Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Melbourne, Australia..
Department of Medicine (St Vincent's), University of Melbourne, Melbourne, Australia..
Endocrinology
School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand..
Psychology Department, University of Florida, Gainesville, Florida, USA..
Issue Date: Sep-2022
Publication information: Addiction Biology 2022; 27(5): e13206
Abstract: Chronic overeating is a core feature of diet-induced obesity. There is increasing evidence that in vulnerable individuals, such overeating could become compulsive, resembling an addictive disorder. The transition to compulsive substance use has been linked with changes at glutamatergic synapses in the nucleus accumbens. In this study, we investigated a potential link between such glutamatergic dysregulation and compulsive-like eating using a rat model of diet-induced obesity. A conditioned suppression task demonstrated that diet-induced obese rats display eating despite negative consequences, as their consumption was insensitive to an aversive cue. Moreover, nucleus accumbens expression of GluA1 and xCT proteins was upregulated in diet-induced obese animals. Lastly, both a computed 'addiction score' (based on performance across three criteria) and weight gain were positively correlated with changes in GluA1 and xCT expression in the nucleus accumbens. These data demonstrate that the propensity for diet-induced obesity is associated with compulsive-like eating of highly palatable food and is accompanied by 'addiction-like' glutamatergic dysregulation in the nucleus accumbens, thus providing neurobiological evidence of addiction-like pathology in this model of obesity.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30820
DOI: 10.1111/adb.13206
ORCID: https://orcid.org/0000-0002-6510-042X
https://orcid.org/0000-0003-4178-9282
https://orcid.org/0000-0003-2524-6739
https://orcid.org/0000-0002-3501-1143
https://orcid.org/0000-0001-6836-727X
https://orcid.org/0000-0003-4167-3634
https://orcid.org/0000-0001-6277-6590
https://orcid.org/0000-0002-9576-1050
https://orcid.org/0000-0002-1420-3381
PubMed URL: 36001420
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/36001420/
Type: Journal Article
Subjects: Sprague-Dawley
compulsive eating
conditioned suppression
glutamate
nucleus accumbens
Appears in Collections:Journal articles

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