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https://ahro.austin.org.au/austinjspui/handle/1/30730| Title: | Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data. | Austin Authors: | Lopez, Seymour M;Aksman, Leon M;Oxtoby, Neil P;Vos, Sjoerd B;Rao, Jun;Kaestner, Erik;Alhusaini, Saud;Alvim, Marina;Bender, Benjamin;Bernasconi, Andrea;Bernasconi, Neda;Bernhardt, Boris;Bonilha, Leonardo;Caciagli, Lorenzo;Caldairou, Benoit;Caligiuri, Maria Eugenia;Calvet, Angels;Cendes, Fernando;Concha, Luis;Conde-Blanco, Estefania;Davoodi-Bojd, Esmaeil;de Bézenac, Christophe;Delanty, Norman;Desmond, Patricia M;Devinsky, Orrin;Domin, Martin;Duncan, John S;Focke, Niels K;Foley, Sonya;Fortunato, Francesco;Galovic, Marian;Gambardella, Antonio;Gleichgerrcht, Ezequiel;Guerrini, Renzo;Hamandi, Khalid;Ives-Deliperi, Victoria;Jackson, Graeme D ;Jahanshad, Neda;Keller, Simon S;Kochunov, Peter;Kotikalapudi, Raviteja;Kreilkamp, Barbara A K;Labate, Angelo;Larivière, Sara;Lenge, Matteo;Lui, Elaine;Malpas, Charles;Martin, Pascal;Mascalchi, Mario;Medland, Sarah E;Meletti, Stefano;Morita-Sherman, Marcia E;Owen, Thomas W;Richardson, Mark;Riva, Antonella;Rüber, Theodor;Sinclair, Ben;Soltanian-Zadeh, Hamid;Stein, Dan J;Striano, Pasquale;Taylor, Peter N;Thomopoulos, Sophia I;Thompson, Paul M;Tondelli, Manuela;Vaudano, Anna Elisabetta;Vivash, Lucy;Wang, Yujiang;Weber, Bernd;Whelan, Christopher D;Wiest, Roland;Winston, Gavin P;Yasuda, Clarissa Lin;McDonald, Carrie R;Alexander, Daniel C;Sisodiya, Sanjay M;Altmann, Andre | Affiliation: | The Florey Institute of Neuroscience and Mental Health Neurology Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK Department of Neurology, University Hospital Zurich, Zurich, Switzerland Department of Neurology, Emory University, Atlanta, USA School of Computing, Newcastle University, Newcastle Upon Tyne, UK Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia Departments of Medicine and Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia Division of Neuroscience, King's College London, London, UK Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia University of Melbourne, Parkville, Victoria, Australia Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia Chalfont Centre for Epilepsy, Chalfont St Peter, UK Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK Wales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany Department of Psychiatry, University of California, San Diego, La Jolla, California, USA Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy Magnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain New York University Grossman School of Medicine, New York, New York, USA Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germany Department of Neurology, University Medical Center, Göttingen, Germany Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA Neuroscience Department, University of Florence, Florence, Italy Neuroscience Institute, University of Cape Town, Cape Town, South Africa Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Florence, Italy Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA Mario Serio Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of Neurology, University of Campinas, Campinas, Brazil Giannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy Department of Epileptology, University Hospital Bonn, Bonn, Germany Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa Giannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Department of Medicine, Division of Neurology, Queen's University, Kingston, Ontario, Canada Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain FutureNeuro SFI Research Centre for Rare and Chronic Neurological Diseases, Dublin, Ireland Primary Care Department, Local Health Authority of Modena, Modena, Italy Department of Clinical Neurophysiology, University Hospital Göttingen, Göttingen, Germany Neurology Unit, OCB Hospital, Modena University Hospital, Modena, Italy Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, A. Meyer Children's Hospital, University of Florence, Florence, Italy |
Issue Date: | Aug-2022 | Date: | 2022-06-25 | Publication information: | Epilepsia 2022; 63(8): 2081-2095 | Abstract: | Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features. We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance. In MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10-16 ), age at onset (ρ = -.18, p = 9.82 × 10-7 ), and ASM resistance (area under the curve = .59, p = .043, Mann-Whitney U test). However, associations were driven by cases assigned to EBM Stage 0, which represents MTLE-HS with mild or nondetectable abnormality on T1W MRI. From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30730 | DOI: | 10.1111/epi.17316 | ORCID: | 0000-0002-8502-4487 0000-0003-3252-5365 0000-0002-6780-0761 0000-0001-9358-5703 0000-0002-8947-9518 0000-0001-9256-6041 0000-0002-2030-5552 0000-0001-9336-9568 0000-0002-7842-3869 0000-0001-7436-987X 0000-0002-2433-9776 0000-0002-3953-9842 0000-0003-0044-4632 0000-0001-5486-6289 0000-0001-8395-7809 0000-0001-7384-3074 0000-0002-4212-4146 0000-0002-7272-7079 0000-0003-2640-249X 0000-0001-5247-9795 0000-0002-8827-7324 0000-0001-5701-1307 0000-0003-0534-3718 0000-0003-0334-539X 0000-0002-8531-3916 0000-0001-9152-5571 0000-0002-6180-7671 0000-0002-0850-3644 0000-0002-6065-1476 0000-0003-2144-9838 0000-0001-6698-5437 0000-0002-6280-7526 0000-0002-1182-0907 0000-0001-9395-1478 0000-0002-1511-5893 0000-0002-9265-2393 0000-0002-7917-5326 |
Journal: | Epilepsia | PubMed URL: | 35656586 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35656586/ | Type: | Journal Article | Subjects: | MTLE disease progression duration of illness event-based model patient staging |
| Appears in Collections: | Journal articles |
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