Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30730
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dc.contributor.authorLopez, Seymour M-
dc.contributor.authorAksman, Leon M-
dc.contributor.authorOxtoby, Neil P-
dc.contributor.authorVos, Sjoerd B-
dc.contributor.authorRao, Jun-
dc.contributor.authorKaestner, Erik-
dc.contributor.authorAlhusaini, Saud-
dc.contributor.authorAlvim, Marina-
dc.contributor.authorBender, Benjamin-
dc.contributor.authorBernasconi, Andrea-
dc.contributor.authorBernasconi, Neda-
dc.contributor.authorBernhardt, Boris-
dc.contributor.authorBonilha, Leonardo-
dc.contributor.authorCaciagli, Lorenzo-
dc.contributor.authorCaldairou, Benoit-
dc.contributor.authorCaligiuri, Maria Eugenia-
dc.contributor.authorCalvet, Angels-
dc.contributor.authorCendes, Fernando-
dc.contributor.authorConcha, Luis-
dc.contributor.authorConde-Blanco, Estefania-
dc.contributor.authorDavoodi-Bojd, Esmaeil-
dc.contributor.authorde Bézenac, Christophe-
dc.contributor.authorDelanty, Norman-
dc.contributor.authorDesmond, Patricia M-
dc.contributor.authorDevinsky, Orrin-
dc.contributor.authorDomin, Martin-
dc.contributor.authorDuncan, John S-
dc.contributor.authorFocke, Niels K-
dc.contributor.authorFoley, Sonya-
dc.contributor.authorFortunato, Francesco-
dc.contributor.authorGalovic, Marian-
dc.contributor.authorGambardella, Antonio-
dc.contributor.authorGleichgerrcht, Ezequiel-
dc.contributor.authorGuerrini, Renzo-
dc.contributor.authorHamandi, Khalid-
dc.contributor.authorIves-Deliperi, Victoria-
dc.contributor.authorJackson, Graeme D-
dc.contributor.authorJahanshad, Neda-
dc.contributor.authorKeller, Simon S-
dc.contributor.authorKochunov, Peter-
dc.contributor.authorKotikalapudi, Raviteja-
dc.contributor.authorKreilkamp, Barbara A K-
dc.contributor.authorLabate, Angelo-
dc.contributor.authorLarivière, Sara-
dc.contributor.authorLenge, Matteo-
dc.contributor.authorLui, Elaine-
dc.contributor.authorMalpas, Charles-
dc.contributor.authorMartin, Pascal-
dc.contributor.authorMascalchi, Mario-
dc.contributor.authorMedland, Sarah E-
dc.contributor.authorMeletti, Stefano-
dc.contributor.authorMorita-Sherman, Marcia E-
dc.contributor.authorOwen, Thomas W-
dc.contributor.authorRichardson, Mark-
dc.contributor.authorRiva, Antonella-
dc.contributor.authorRüber, Theodor-
dc.contributor.authorSinclair, Ben-
dc.contributor.authorSoltanian-Zadeh, Hamid-
dc.contributor.authorStein, Dan J-
dc.contributor.authorStriano, Pasquale-
dc.contributor.authorTaylor, Peter N-
dc.contributor.authorThomopoulos, Sophia I-
dc.contributor.authorThompson, Paul M-
dc.contributor.authorTondelli, Manuela-
dc.contributor.authorVaudano, Anna Elisabetta-
dc.contributor.authorVivash, Lucy-
dc.contributor.authorWang, Yujiang-
dc.contributor.authorWeber, Bernd-
dc.contributor.authorWhelan, Christopher D-
dc.contributor.authorWiest, Roland-
dc.contributor.authorWinston, Gavin P-
dc.contributor.authorYasuda, Clarissa Lin-
dc.contributor.authorMcDonald, Carrie R-
dc.contributor.authorAlexander, Daniel C-
dc.contributor.authorSisodiya, Sanjay M-
dc.contributor.authorAltmann, Andre-
dc.date2022-06-25-
dc.date.accessioned2022-08-16T06:58:10Z-
dc.date.available2022-08-16T06:58:10Z-
dc.date.issued2022-08-
dc.identifier.citationEpilepsia 2022; 63(8): 2081-2095en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30730-
dc.description.abstractRecent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features. We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance. In MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10-16 ), age at onset (ρ = -.18, p = 9.82 × 10-7 ), and ASM resistance (area under the curve = .59, p = .043, Mann-Whitney U test). However, associations were driven by cases assigned to EBM Stage 0, which represents MTLE-HS with mild or nondetectable abnormality on T1W MRI. From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.en
dc.language.isoeng
dc.subjectMTLEen
dc.subjectdisease progressionen
dc.subjectduration of illnessen
dc.subjectevent-based modelen
dc.subjectpatient stagingen
dc.titleEvent-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationNeurologyen
dc.identifier.affiliationDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UKen
dc.identifier.affiliationDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UKen
dc.identifier.affiliationDepartment of Neurology, University Hospital Zurich, Zurich, Switzerlanden
dc.identifier.affiliationDepartment of Neurology, Emory University, Atlanta, USAen
dc.identifier.affiliationSchool of Computing, Newcastle University, Newcastle Upon Tyne, UKen
dc.identifier.affiliationDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartments of Medicine and Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDivision of Neuroscience, King's College London, London, UKen
dc.identifier.affiliationPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australiaen
dc.identifier.affiliationUniversity of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationChalfont Centre for Epilepsy, Chalfont St Peter, UKen
dc.identifier.affiliationCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UKen
dc.identifier.affiliationStevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USAen
dc.identifier.affiliationCentre for Medical Image Computing, Department of Computer Science, University College London, London, UKen
dc.identifier.affiliationNeuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UKen
dc.identifier.affiliationDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UKen
dc.identifier.affiliationWales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UKen
dc.identifier.affiliationInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UKen
dc.identifier.affiliationClinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germanyen
dc.identifier.affiliationDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USAen
dc.identifier.affiliationDepartment of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USAen
dc.identifier.affiliationMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canadaen
dc.identifier.affiliationNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canadaen
dc.identifier.affiliationInstitute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italyen
dc.identifier.affiliationMagnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spainen
dc.identifier.affiliationDepartment of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazilen
dc.identifier.affiliationInstitute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexicoen
dc.identifier.affiliationEpilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spainen
dc.identifier.affiliationNew York University Grossman School of Medicine, New York, New York, USAen
dc.identifier.affiliationFunctional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Medical Center, Göttingen, Germanyen
dc.identifier.affiliationDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina, USAen
dc.identifier.affiliationNeuroscience Department, University of Florence, Florence, Italyen
dc.identifier.affiliationNeuroscience Institute, University of Cape Town, Cape Town, South Africaen
dc.identifier.affiliationDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germanyen
dc.identifier.affiliationNeuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italyen
dc.identifier.affiliationPediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Florence, Italyen
dc.identifier.affiliationDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USAen
dc.identifier.affiliationMario Serio Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italyen
dc.identifier.affiliationDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italyen
dc.identifier.affiliationDepartment of Neurology, University of Campinas, Campinas, Brazilen
dc.identifier.affiliationGiannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italyen
dc.identifier.affiliationDepartment of Epileptology, University Hospital Bonn, Bonn, Germanyen
dc.identifier.affiliationRadiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USAen
dc.identifier.affiliationSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africaen
dc.identifier.affiliationGiannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italyen
dc.identifier.affiliationImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USAen
dc.identifier.affiliationInstitute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germanyen
dc.identifier.affiliationSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerlanden
dc.identifier.affiliationDepartment of Medicine, Division of Neurology, Queen's University, Kingston, Ontario, Canadaen
dc.identifier.affiliationDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italyen
dc.identifier.affiliationDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germanyen
dc.identifier.affiliationCleveland Clinic Neurological Institute, Cleveland, Ohio, USAen
dc.identifier.affiliationSchool of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iranen
dc.identifier.affiliationDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Irelanden
dc.identifier.affiliationAugust Pi i Sunyer Biomedical Research Institute, Barcelona, Spainen
dc.identifier.affiliationFutureNeuro SFI Research Centre for Rare and Chronic Neurological Diseases, Dublin, Irelanden
dc.identifier.affiliationPrimary Care Department, Local Health Authority of Modena, Modena, Italyen
dc.identifier.affiliationDepartment of Clinical Neurophysiology, University Hospital Göttingen, Göttingen, Germanyen
dc.identifier.affiliationNeurology Unit, OCB Hospital, Modena University Hospital, Modena, Italyen
dc.identifier.affiliationFunctional and Epilepsy Neurosurgery Unit, Neurosurgery Department, A. Meyer Children's Hospital, University of Florence, Florence, Italyen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35656586/en
dc.identifier.doi10.1111/epi.17316en
dc.type.contentTexten
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dc.identifier.pubmedid35656586
local.name.researcherJackson, Graeme D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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