A companion to the preclinical common data elements for genomics, transcriptomics and epigenomics data in rodent epilepsy models. A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force.

2022-08-11

van Vliet, Erwin A

Hildebrand, Michael S

Mills, James D

Brennan, Gary P

Eid, Tore

Masino, Susan A

Whittemore, Vicky

Bindila, Laura

Wang, Kevin K

Patel, Manisha

Perucca, Piero

Reid, Christopher A

common data elements

mouse

omic data processing

preclinical

rat

Journal Article

0000-0001-5747-3202

0000-0001-9217-6393

0000-0003-4237-4900

0000-0002-7855-7066

0000-0002-1457-8028

0000-0003-2739-0515

10.1002/epi4.12640

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two-part series of omics papers with the second instalment to cover proteomics, lipidomics, and metabolomics in adult rodents.

link

Epilepsia Open 2022; online first: 11 August

Epilepsia Open