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https://ahro.austin.org.au/austinjspui/handle/1/30706| Title: | Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage. | Austin Authors: | Vourc'h, Mickael;Roquilly, Antoine;Foucher, Adrien;Retiere, Christelle;Feuillet, Fanny;Devi, Sapna;McWilliam, Hamish E G;Braudeau, Cecile;Bourreille, Geraldine;Hachani, Abderrahman;O'Kane, Dermot B ;Mueller, Scott N;Ischia, Joseph J ;Roussel, Jean-Christian;Rigal, Jean-Christophe;Josien, Regis;Rozec, Bertrand;Villadangos, Jose A;Asehnoune, Karim | Affiliation: | Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.. Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.. Surgery (University of Melbourne) Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.. Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France and Etablissement Français du Sang Centre Pays de la Loire, Nantes, France and LabEx IGO "Immunotherapy, Graft, Oncology".. Plateforme de Méthodologie et Biostatistique, France, Université de Nantes, INSERM, SPHERE U1246, France.. CHU Nantes, Nantes Université, Laboratoire d'immunologie, CIMNA, and Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.. Etablissement Français du Sang (EFS) Pays-de-Loire, Nantes, France.. Cardiac Surgery Department, Hôpital Laennec, CHU Nantes, Nantes, France.. Cardiac Surgery Intensive Care Unit, Hôpital Laennec, CHU Nantes, Nantes, France.. Nantes University, CHU Nantes, CNRS, Inserm, Institut du Thorax, Nantes, France.. CHU de Nantes, Service d'Anesthésie Réanimation, Nantes, France.. Urology Surgical Intensive Care Unit, Hôtel Dieu, CHU Nantes, Nantes, France.. |
Issue Date: | 1-Jun-2022 | Date: | 2022-07 | Publication information: | JACC. Basic to Translational Science 2022; 7(7): 627-638 | Abstract: | Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30706 | DOI: | 10.1016/j.jacbts.2022.02.019 | ORCID: | 0000-0002-8344-9537 0000-0001-7177-3631 |
Journal: | JACC. Basic to Translational Science | PubMed URL: | 35958696 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35958696/ | Type: | Journal Article | Subjects: | AKI, acute kidney injury CPB, cardiopulmonary bypass IRI, ischemia-reperfusion injury MPO, myeloperoxidase MRP_14, myeloid-related protein 14 PRBC, packed red blood cells acute kidney injury cardiac surgery neutrophils packed red blood cells transfusion transfusion safety trogocytosis |
| Appears in Collections: | Journal articles |
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