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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30706
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dc.contributor.authorVourc'h, Mickael-
dc.contributor.authorRoquilly, Antoine-
dc.contributor.authorFoucher, Adrien-
dc.contributor.authorRetiere, Christelle-
dc.contributor.authorFeuillet, Fanny-
dc.contributor.authorDevi, Sapna-
dc.contributor.authorMcWilliam, Hamish E G-
dc.contributor.authorBraudeau, Cecile-
dc.contributor.authorBourreille, Geraldine-
dc.contributor.authorHachani, Abderrahman-
dc.contributor.authorO'Kane, Dermot B-
dc.contributor.authorMueller, Scott N-
dc.contributor.authorIschia, Joseph J-
dc.contributor.authorRoussel, Jean-Christian-
dc.contributor.authorRigal, Jean-Christophe-
dc.contributor.authorJosien, Regis-
dc.contributor.authorRozec, Bertrand-
dc.contributor.authorVilladangos, Jose A-
dc.contributor.authorAsehnoune, Karim-
dc.date2022-07-
dc.date.accessioned2022-08-16T06:57:45Z-
dc.date.available2022-08-16T06:57:45Z-
dc.date.issued2022-06-01-
dc.identifier.citationJACC. Basic to Translational Science 2022; 7(7): 627-638en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30706-
dc.description.abstractTransfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.en
dc.language.isoeng
dc.subjectAKI, acute kidney injuryen
dc.subjectCPB, cardiopulmonary bypassen
dc.subjectIRI, ischemia-reperfusion injuryen
dc.subjectMPO, myeloperoxidaseen
dc.subjectMRP_14, myeloid-related protein 14en
dc.subjectPRBC, packed red blood cellsen
dc.subjectacute kidney injuryen
dc.subjectcardiac surgeryen
dc.subjectneutrophilsen
dc.subjectpacked red blood cellsen
dc.subjecttransfusionen
dc.subjecttransfusion safetyen
dc.subjecttrogocytosisen
dc.titleTransfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage.en
dc.typeJournal Articleen
dc.identifier.journaltitleJACC. Basic to Translational Scienceen
dc.identifier.affiliationNantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France..en
dc.identifier.affiliationDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia..en
dc.identifier.affiliationSurgery (University of Melbourne)en
dc.identifier.affiliationNantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France..en
dc.identifier.affiliationNantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France and Etablissement Français du Sang Centre Pays de la Loire, Nantes, France and LabEx IGO "Immunotherapy, Graft, Oncology"..en
dc.identifier.affiliationPlateforme de Méthodologie et Biostatistique, France, Université de Nantes, INSERM, SPHERE U1246, France..en
dc.identifier.affiliationCHU Nantes, Nantes Université, Laboratoire d'immunologie, CIMNA, and Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France..en
dc.identifier.affiliationEtablissement Français du Sang (EFS) Pays-de-Loire, Nantes, France..en
dc.identifier.affiliationCardiac Surgery Department, Hôpital Laennec, CHU Nantes, Nantes, France..en
dc.identifier.affiliationCardiac Surgery Intensive Care Unit, Hôpital Laennec, CHU Nantes, Nantes, France..en
dc.identifier.affiliationNantes University, CHU Nantes, CNRS, Inserm, Institut du Thorax, Nantes, France..en
dc.identifier.affiliationCHU de Nantes, Service d'Anesthésie Réanimation, Nantes, France..en
dc.identifier.affiliationUrologyen
dc.identifier.affiliationSurgical Intensive Care Unit, Hôtel Dieu, CHU Nantes, Nantes, France..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35958696/en
dc.identifier.doi10.1016/j.jacbts.2022.02.019en
dc.type.contentTexten
dc.identifier.orcid0000-0002-8344-9537en
dc.identifier.orcid0000-0001-7177-3631en
dc.identifier.pubmedid35958696
local.name.researcherIschia, Joseph J
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptUrology-
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