Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30552
Title: A cohort study of the efficacy and safety of immune checkpoint inhibitors plus anlotinib versus immune checkpoint inhibitors alone as the treatment of advanced non-small cell lung cancer in the real world.
Austin Authors: Shi, Yue;Ji, Min;Jiang, Yingying;Yin, Rong;Wang, Zihan;Li, Hang;Wang, Shuaiyu;He, Kang;Ma, Yuxin;Wang, Zhitong;Lu, Jianwei;Shi, Meiqi;Shen, Bo;Zhou, Guoren;Leong, Tracy L ;Wang, Xiaohua;Chen, Cheng;Feng, Jifeng
Affiliation: Department of Oncology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China..
Department of Radiotherapy, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China..
Department of Thoracic Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China..
School of Life Science, Nantong University, Nantong, China..
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA..
UCL School of Pharmacy, University College London, London, UK..
Department of Radiotherapy, Nanjing Medical University, Nanjing, China..
Respiratory and Sleep Medicine
Issue Date: Jun-2022
Publication information: Translational lung cancer research 2022; 11(6): 1051-1068
Abstract: Anlotinib is a new multi-target tyrosine kinase inhibitor (TKI) and has been shown to have antitumor effects and synergistic antitumor effects with immunotherapy only in animal studies and in the 2nd-line treatment in small clinical trials. A real-world study with large sample to compare the efficacy and safety of anlotinib plus immune checkpoint inhibitors (ICIs) with ICIs alone in the multiline treatment of advanced non-small cell lung cancer (NSCLC) was urgently needed. The data of 535 advanced NSCLC patients were collected from January 1, 2018, to December 31, 2021. The patients were divided into 2 groups: (I) ICI monotherapy (230 patients); (II) ICI + anlotinib (305 patients). After propensity-score matching (PSM) to reduce the effects of biases and confounding variables, the progression-free survival time (PFS), occurrence of adverse events, disease control rate (DCR), and objective response rate (ORR) of the 2 groups were compared. The effects of clinical factors, including age, gender, gene mutations, tumor proportion score, metastases, and combined radiotherapy, were also analyzed. After PSM, the baseline clinical characteristics were well balanced and the 2 group had a good comparability. Patients in the ICI + anlotinib group had significantly longer median PFS in both the 2nd-line treatment (7.73 vs. 4.70 months; P=0.003) and 3rd-line treatment (5.90 vs. 3.37 months; P=0.020), but the difference lacked statistical significance in the 1st-line treatment (8.40 vs. 5.20 months; P=0.229). The overall median PFS of patients in the ICI + anlotinib group was also much longer than that of patients in the ICI monotherapy group (6.37 vs. 3.90 months; P<0.001). The ICI + anlotinib group also tended to have a higher DCR, a higher ORR, and a higher probability of severe adverse drug reactions during the treatment than the ICI monotherapy group, but the differences were not statistically significant. Combining ICI + anlotinib could improve the outcomes of patients with bone metastasis. Anlotinib + ICI therapy could have greater efficacy in the treatment of advanced NSCLC patients than ICI monotherapy. The probability of adverse events might increase in the combined treatment, but could be controlled.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30552
DOI: 10.21037/tlcr-22-350
Journal: Translational lung cancer research
PubMed URL: 35832459
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35832459/
ISSN: 2218-6751
Type: Journal Article
Subjects: Non-small cell lung cancer (NSCLC)
anlotinib
combined therapy
immunotherapy
Appears in Collections:Journal articles

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