Please use this identifier to cite or link to this item:
Title: Comparison of 6-month outcomes of sepsis versus non-sepsis critically ill patients receiving mechanical ventilation.
Austin Authors: Hodgson, Carol L;Higgins, Alisa M;Bailey, Michael;Barrett, Jonathon;Bellomo, Rinaldo ;Cooper, D James;Gabbe, Belinda J;Iwashyna, Theodore;Linke, Natalie;Myles, Paul S;Paton, Michelle;Philpot, Steve;Shulman, Mark;Young, Meredith;Serpa Neto, Ary 
Affiliation: Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil..
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia..
Department of Anaesthesiology and Perioperative Medicine, The Alfred, Melbourne, VIC, Australia..
Department of Physiotherapy, Monash Health, Melbourne, VIC, Australia..
Intensive Care Unit, Cabrini Health, Melbourne, VIC, Australia..
Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia..
Intensive Care
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia..
Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia..
Intensive Care Unit, Epworth Healthcare, Melbourne, VIC, Australia..
Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia..
Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, USA..
Centre for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA..
Issue Date: 13-Jun-2022
Date: 2022
Publication information: Critical care (London, England) 2022; 26(1): 174
Abstract: Data on long-term outcomes after sepsis-associated critical illness have mostly come from small cohort studies, with no information about the incidence of new disability. We investigated whether sepsis-associated critical illness was independently associated with new disability at 6 months after ICU admission compared with other types of critical illness. We conducted a secondary analysis of a multicenter, prospective cohort study in six metropolitan intensive care units in Australia. Adult patients were eligible if they had been admitted to the ICU and received more than 24 h of mechanical ventilation. There was no intervention. The primary outcome was new disability measured with the WHO Disability Assessment Schedule 2.0 (WHODAS) 12 level score compared between baseline and 6 months. Between enrollment and follow-up at 6 months, 222/888 (25%) patients died, 100 (35.5%) with sepsis and 122 (20.1%) without sepsis (P < 0.001). Among survivors, there was no difference for the incidence of new disability at 6 months with or without sepsis, 42/106 (39.6%) and 106/300 (35.3%) (RD, 0.00 (- 10.29 to 10.40), P = 0.995), respectively. In addition, there was no difference in the severity of disability, health-related quality of life, anxiety and depression, post-traumatic stress, return to work, financial distress or cognitive function. Compared to mechanically ventilated patients of similar acuity and length of stay without sepsis, patients with sepsis admitted to ICU have an increased risk of death, but survivors have a similar risk of new disability at 6 months. Trial registration NCT03226912, registered July 24, 2017.
DOI: 10.1186/s13054-022-04041-w
ORCID: 0000-0001-9002-2075
Journal: Critical care (London, England)
PubMed URL: 35698201
PubMed URL:
Type: Journal Article
Subjects: Critical illness
Intensive care
Mechanical ventilation
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Nov 29, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.