Please use this identifier to cite or link to this item:
Title: Helicobacter pylori and the Role of Lipopolysaccharide Variation in Innate Immune Evasion.
Austin Authors: Sijmons, Daniel;Guy, Andrew J;Walduck, Anna K;Ramsland, Paul A 
Affiliation: Surgery (University of Melbourne)..
Department of Immunology, Monash University, Melbourne, VIC, Australia..
School of Science, RMIT University, Melbourne, VIC, Australia..
ZiP Diagnostics, Collingwood, VIC, Australia..
Issue Date: 13-May-2022
Date: 2022
Publication information: Frontiers in immunology 2022; 13: 868225.
Abstract: Helicobacter pylori is an important human pathogen that infects half the human population and can lead to significant clinical outcomes such as acute and chronic gastritis, duodenal ulcer, and gastric adenocarcinoma. To establish infection, H. pylori employs several mechanisms to overcome the innate and adaptive immune systems. H. pylori can modulate interleukin (IL) secretion and innate immune cell function by the action of several virulence factors such as VacA, CagA and the type IV secretion system. Additionally, H. pylori can modulate local dendritic cells (DC) negatively impacting the function of these cells, reducing the secretion of immune signaling molecules, and influencing the differentiation of CD4+ T helper cells causing a bias to Th1 type cells. Furthermore, the lipopolysaccharide (LPS) of H. pylori displays a high degree of phase variation and contains human blood group carbohydrate determinants such as the Lewis system antigens, which are proposed to be involved in molecular mimicry of the host. Lastly, the H. pylori group of outer membrane proteins such as BabA play an important role in attachment and interaction with host Lewis and other carbohydrate antigens. This review examines the various mechanisms that H. pylori utilises to evade the innate immune system as well as discussing how the structure of the H. pylori LPS plays a role in immune evasion.
DOI: 10.3389/fimmu.2022.868225
ORCID: 0000-0002-2107-2738
Journal: Frontiers in immunology
PubMed URL: 35634347
PubMed URL:
Type: Journal Article
Subjects: H. pylori
Lewis system antigens
dendritic cells
innate immunity
molecular mimicry
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Dec 3, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.