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https://ahro.austin.org.au/austinjspui/handle/1/30263| Title: | SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity. | Austin Authors: | Zhang, Wuji;Chua, Brendon Y;Selva, Kevin J;Kedzierski, Lukasz;Ashhurst, Thomas M;Haycroft, Ebene R;Shoffner-Beck, Suzanne K;Hensen, Luca;Boyd, David F;James, Fiona L ;Mouhtouris, Effie ;Kwong, Jason C ;Chua, Kyra Y L ;Drewett, George P ;Copaescu, Ana ;Dobson, Julie E ;Rowntree, Louise C;Habel, Jennifer R;Allen, Lilith F;Koay, Hui-Fern;Neil, Jessica A;Gartner, Matthew J;Lee, Christina Y;Andersson, Patiyan;Khan, Sadid F;Blakeway, Luke;Wisniewski, Jessica;McMahon, James H;Vine, Erica E;Cunningham, Anthony L;Audsley, Jennifer;Thevarajan, Irani;Seemann, Torsten;Sherry, Norelle L ;Amanat, Fatima;Krammer, Florian;Londrigan, Sarah L;Wakim, Linda M;King, Nicholas J C;Godfrey, Dale I;Mackay, Laura K;Thomas, Paul G;Nicholson, Suellen;Arnold, Kelly B;Chung, Amy W;Holmes, Natasha E ;Smibert, Olivia C ;Trubiano, Jason ;Gordon, Claire L ;Nguyen, Thi H O;Kedzierska, Katherine | Affiliation: | Victorian Infectious Diseases Services, The Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, 3000, VIC, Australia.. Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia.. Department of Infectious Diseases, Monash Medical Centre, Melbourne, VIC, Australia.. Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.. School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.. Sydney Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.. Infectious Diseases Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.. National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.. Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.. Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.. Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia.. Radiology Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, 3000, Australia.. Department of Critical Care, University of Melbourne, Parkville, VIC, Australia.. Data Analytics Research and Evaluation (DARE) Centre Centre for Antibiotic Allergy and Research Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.. Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.. Medicine (University of Melbourne) Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.. Viral Immunopathology Laboratory, Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.. Sydney Nano, University of Sydney, Sydney, NSW, 2006, Australia.. Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.. Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.. Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.. Department of Biomedical Engineering, University of Michigan, Michigan, USA.. Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.. Department of Biomedical Engineering, University of Michigan, Michigan, USA.. |
Issue Date: | 19-May-2022 | Date: | 2022 | Publication information: | Nature communications 2022; 13(1): 2774 | Abstract: | Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune components in longitudinal blood and respiratory samples from hospitalized COVID-19 patients. SARS-CoV-2-specific IgM, IgG, IgA are detected in respiratory tract and blood, however, receptor-binding domain (RBD)-specific IgM and IgG seroconversion is enhanced in respiratory specimens. SARS-CoV-2 neutralization activity in respiratory samples correlates with RBD-specific IgM and IgG levels. Cytokines/chemokines vary between respiratory samples and plasma, indicating that inflammation should be assessed in respiratory specimens to understand immunopathology. IFN-α2 and IL-12p70 in endotracheal aspirate and neutralization in sputum negatively correlate with duration of hospital stay. Diverse immune subsets are detected in respiratory samples, dominated by neutrophils. Importantly, dexamethasone treatment does not affect humoral responses in blood of COVID-19 patients. Our study unveils differential immune responses between respiratory samples and blood, and shows how drug therapy affects immune responses during COVID-19. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30263 | DOI: | 10.1038/s41467-022-30088-y | ORCID: | http://orcid.org/0000-0001-7460-4956 http://orcid.org/0000-0001-7269-7773 http://orcid.org/0000-0002-5059-3030 http://orcid.org/0000-0003-0010-6318 http://orcid.org/0000-0003-1383-4939 http://orcid.org/0000-0003-0469-5666 http://orcid.org/0000-0001-8826-7137 http://orcid.org/0000-0003-0380-1527 http://orcid.org/0000-0002-3236-9609 http://orcid.org/0000-0003-2824-3701 http://orcid.org/0000-0002-9393-2178 http://orcid.org/0000-0002-9923-6579 http://orcid.org/0000-0003-4441-3301 http://orcid.org/0000-0002-6744-5667 http://orcid.org/0000-0001-6322-3197 http://orcid.org/0000-0002-7789-8360 http://orcid.org/0000-0002-8029-8227 http://orcid.org/0000-0003-4121-776X http://orcid.org/0000-0003-0989-4971 http://orcid.org/0000-0003-1752-9579 http://orcid.org/0000-0002-3877-9772 http://orcid.org/0000-0002-3009-5472 http://orcid.org/0000-0002-8496-6632 http://orcid.org/0000-0001-7955-0256 http://orcid.org/0000-0001-6585-7150 http://orcid.org/0000-0003-4756-7461 http://orcid.org/0000-0003-0020-9704 http://orcid.org/0000-0001-5172-4728 http://orcid.org/0000-0002-9294-7693 http://orcid.org/0000-0001-6141-335X http://orcid.org/0000-0003-3491-2633 http://orcid.org/0000-0002-6298-7942 http://orcid.org/0000-0002-9439-0251 http://orcid.org/0000-0002-9183-5032 http://orcid.org/0000-0001-8501-4054 http://orcid.org/0000-0003-1232-5884 http://orcid.org/0000-0002-5111-6367 |
Journal: | Nature communications | PubMed URL: | 35589689 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35589689/ | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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