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Title: Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.
Austin Authors: Zavaliangos-Petropulu, Artemis;Lo, Bethany;Donnelly, Miranda R;Schweighofer, Nicolas;Lohse, Keith;Jahanshad, Neda;Barisano, Giuseppe;Banaj, Nerisa;Borich, Michael R;Boyd, Lara A;Buetefisch, Cathrin M;Byblow, Winston D;Cassidy, Jessica M;Charalambous, Charalambos C;Conforto, Adriana B;DiCarlo, Julie A;Dula, Adrienne N;Egorova-Brumley, Natalia;Etherton, Mark R;Feng, Wuwei;Fercho, Kelene A;Geranmayeh, Fatemeh;Hanlon, Colleen A;Hayward, Kathryn S ;Hordacre, Brenton;Kautz, Steven A;Khlif, Mohamed Salah;Kim, Hosung;Kuceyeski, Amy;Lin, David J;Liu, Jingchun;Lotze, Martin;MacIntosh, Bradley J;Margetis, John L;Mohamed, Feroze B;Piras, Fabrizio;Ramos-Murguialday, Ander;Revill, Kate P;Roberts, Pamela S;Robertson, Andrew D;Schambra, Heidi M;Seo, Na Jin;Shiroishi, Mark S;Stinear, Cathy M;Soekadar, Surjo R;Spalletta, Gianfranco;Taga, Myriam;Tang, Wai Kwong;Thielman, Gregory T;Vecchio, Daniela;Ward, Nick S;Westlye, Lars T;Werden, Emilio ;Winstein, Carolee;Wittenberg, George F;Wolf, Steven L;Wong, Kristin A;Yu, Chunshui;Brodtmann, Amy ;Cramer, Steven C;Thompson, Paul M;Liew, Sook-Lei
Affiliation: The Florey Institute of Neuroscience and Mental Health
Medicine (University of Melbourne)
Melbourne Dementia Research Center University of Melbourne Victoria Australia
Neuroscience Graduate Program University of Southern California Los Angeles CA
Melbourne School of Psychological Sciences University of Melbourne Parkville Victoria Australia
Innovation, Implementation and Clinical Translation (IIMPACT) in Health Allied Health and Human Performance University of South Australia, Adelaide, South Australia, Australia
Physical Therapy and Neurology Washington University School of Medicine in Saint Louis MO
Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine, University of Southern California Los Angeles CA
Division of Physical Therapy Department of Rehabilitation Medicine Emory University School of Medicine Atlanta GA
Department of Physical Therapy University of British Columbia Vancouver Canada
Department of Neurology School of Medicine Emory University Atlanta GA
Department of Exercise Sciences, and Centre for Brain Research University of Auckland New Zealand
Department of Allied Health Sciences University of North Carolina at Chapel Hill NC
Center for Neuroscience and Integrative Brain Research (CENIBRE) Nicosia Cyprus
Hospital das Clínicas São Paulo University São Paulo Brazil
Department of Neurology Dell Medical School University of Texas at Austin TX
Department of Neurology J. Philip Kistler Stroke Research Center Massachusetts General Hospital Boston MA
Department of Neurology Duke University School of Medicine Durham NC
Basic Biomedical Sciences University of South Dakota Vermillion SD
Brain Sciences Imperial College London London United Kingdom
Wake Forest School of Medicine Winston Salem NC
Department of Radiology Weill Cornell Medicine New York NY
Center for Neurotechnology and Neurorecovery (CNTR) Massachusetts General Hospital Boston MA
Functional Imaging Institute for Diagnostic Radiology and Neuroradiology University Medicine Greifswald Germany
Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Canada
Department of Radiology Jefferson Integrated MR Center Thomas Jefferson University Philadelphia PA
Institute of Medical Psychology and Behavioral Neurobiology University of Tübingen Germany
Department of Psychology Emory University Atlanta GA
Department of Physical Medicine and Rehabilitation Cedars-Sinai Los Angeles CA
Department of Kinesiology and Health Sciences University of Waterloo Ontario Canada
Departments of Neurology & Rehabilitation Medicine NYU Langone New York NY
Ralph H Johnson Veterans Affairs Medical Center Charleston SC
Department of Radiology Keck School of Medicine University of Southern California Los Angeles CA
Department of Medicine University of Auckland New Zealand
Clinical Neurotechnology Laboratory Department of Psychiatry and Neurosciences (CCM) Charité - Universitätsmedizin Berlin Berlin Germany
NYU Langone Department of Neurology New York NY
Department of Psychiatry The Chinese University of Hong Kong China
Department of Physical Therapy and Neuroscience University of the Sciences Philadelphia PA
Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy
University College London Queen Square Institute of Neurology London United Kingdom
Department of Psychology University of Oslo Norway
Department of Veterans Affairs Geriatrics Research Educational & Clinical Center Veterans Affairs Pittsburgh Healthcare System (VAPHS) Pittsburgh PA
Department of Medicine Emory University School of Medicine Atlanta GA
Department of Physical Medicine & Rehabilitation Dell Medical School University of Texas at Austin TX
Department of Radiology Tianjin Medical University General Hospital Tianjin China
California Rehabilitation Hospital Los Angeles CA
Hospital Israelita Albert Einstein São Paulo Brazil
Federal Aviation Administration Civil Aerospace Medical Institute Oklahoma City OK
Department of Mental Health and Addiction Oslo University Hospital Oslo Norway
Biokinesiology and Physical Therapy University of Southern California Los Angeles CA
Department of Rehabilitation Sciences Department of Health Science and Research Medical University of South Carolina Charleston SC
Department of Medical Biophysics University of Toronto Ontario Canada
Department of Health Sciences & Research Medical University of South Carolina Charleston SC
Department of Basic and Clinical Sciences University of Nicosia Medical School Nicosia Cyprus
Department of Neurology University of Pittsburgh PA
Department of Neurology University of California Los Angeles David Geffen School of Medicine Los Angeles CA
Health Division TECNALIA San Sebastian Spain
Chan Division of Occupational Science and Occupational Therapy University of Southern California Los Angeles CA
Issue Date: 17-May-2022 2022
Publication information: Journal of the American Heart Association 2022; 11(10): e025109
Abstract: Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=-0.26) and contralesional (P=0.006; β=-0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=-0.21) and extent of sensorimotor damage (P=0.003; β=-0.15). Conclusions The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
DOI: 10.1161/JAHA.121.025109
ORCID: 0000-0003-1953-8663
Journal: Journal of the American Heart Association
PubMed URL: 35574963
PubMed URL:
Type: Journal Article
Subjects: MRI
sensorimotor impairment
Appears in Collections:Journal articles

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