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Title: Contemporary Concise Review 2021: Pulmonary nodules from detection to intervention.
Austin Authors: Stone, Emily;Leong, Tracy L 
Affiliation: Respiratory and Sleep Medicine
Department of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia..
School of Clinical Medicine, UNSW, Sydney, New South Wales, Australia..
School of Public Health, University of Sydney, Sydney, New South Wales, Australia..
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia..
Issue Date: 17-May-2022
Date: 2022
Publication information: Respirology (Carlton, Vic.) 2022; 27(9): 776-785
Abstract: The US Preventive Task Force (USPSTF) has updated screening criteria by expanding age range and reducing smoking history required for eligibility; the International Lung Screen Trial (ILST) data have shown that PLCOM2012 performs better for eligibility than USPSTF criteria. Screening adherence is low (4%-6% of potential eligible candidates in the United States) and depends upon multiple system and patient/candidate-related factors. Smoking cessation in lung cancer improves survival (past prospective trial data, updated meta-analysis data); smoking cessation is an essential component of lung cancer screening. Circulating biomarkers are emerging to optimize screening and early diagnosis. COVID-19 continues to affect lung cancer treatment and screening through delays and disruptions; specific operational challenges need to be met. Over 70% of suspected malignant lesions develop in the periphery of the lungs. Bronchoscopic navigational techniques have been steadily improving to allow greater accuracy with target lesion approximation and therefore diagnostic yield. Fibre-based imaging techniques provide real-time microscopic tumour visualization, with potential diagnostic benefits. With significant advances in peripheral lung cancer localization, bronchoscopically delivered ablative therapies are an emerging field in limited stage primary and oligometastatic disease. In advanced stage lung cancer, small-volume samples acquired through bronchoscopic techniques yield material of sufficient quantity and quality to support clinically relevant biomarker assessment.
DOI: 10.1111/resp.14296
ORCID: 0000-0001-9021-8449
Journal: Respirology (Carlton, Vic.)
PubMed URL: 35581532
PubMed URL:
Type: Journal Article
Subjects: biomarkers
interventional pulmonology
lung cancer
navigational bronchoscopy
Appears in Collections:Journal articles

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