Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30155
Title: Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis.
Austin Authors: Kleissl-Muir, Sabine;Rasmussen, Bodil;Owen, Alice;Zinn, Caryn;Driscoll, Andrea 
Affiliation: Cardiology
Centre for Quality and Patient Safety, School of Nursing and Midwifery, Institute for Health Transformation, Deakin University, Geelong, VIC, Australia
Faculty of Health Sciences, University of Southern Denmark and Steno Diabetes Centre, Odense, Denmark
The Centre for Quality and Patient Safety, Institute of Health Transformation -Western Health Partnership, Western Health, St Albans, VIC, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
School of Nursing and Midwifery, Deakin University, Geelong, VIC, Australia
Human Potential Centre, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Issue Date: 20-Apr-2022
Date: 2022
Publication information: Frontiers in Nutrition 2022; 9: 865489
Abstract: Elevated blood glucose levels, insulin resistance (IR), hyperinsulinemia and dyslipidemia the key aspects of type 2 diabetes mellitus (T2DM), contribute to the development of a certain form of cardiomyopathy. This cardiomyopathy, also known as diabetic cardiomyopathy (DMCM), typically occurs in the absence of overt coronary artery disease (CAD), hypertension or valvular disease. DMCM encompasses a variety of pathophysiological processes impacting the myocardium, hence increasing the risk for heart failure (HF) and significantly worsening outcomes in this population. Low fat (LF), calorie-restricted diets have been suggested as the preferred eating pattern for patients with HF. However, LF diets are naturally higher in carbohydrates (CHO). We argue that in an insulin resistant state, such as in DMCM, LF diets may worsen glycaemic control and promote further insulin resistance (IR), contributing to a physiological and functional decline in DMCM. We postulate that CHO restriction targeting hyperinsulinemia may be able to improve tissue and systemic IR. In recent years low carbohydrate diets (LC) including ketogenic diets (KD), have emerged as a safe and effective tool for the management of various clinical conditions such as T2DM and other metabolic disorders. CHO restriction achieves sustained glycaemic control, lower insulin levels and successfully reverses IR. In addition to this, its pleiotropic effects may present a metabolic stress defense and facilitate improvement to cardiac function in patients with HF. We therefore hypothesize that patients who adopt a LC diet may require less medications and experience improvements in HF-related symptom burden.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30155
DOI: 10.3389/fnut.2022.865489
Journal: Frontiers in Nutrition
PubMed URL: 35529461
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35529461/
ISSN: 2296-861X
Type: Journal Article
Subjects: diabetes
diabetic cardiomyopathy
heart failure
insulin resistance
ketogenic diet
low carbohydrate diet
Appears in Collections:Journal articles

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