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Title: Unexpected case of accelerated silicosis in a female quarry worker.
Austin Authors: Leong, Tracy L ;Wimaleswaran, Hari ;Williams, David S ;Goh, Nicole S L ;Hoy, Ryan F
Affiliation: Respiratory and Sleep Medicine
Anatomical Pathology
Monash University Centre for Occupational and Environmental Health, VIC, Australia
Department of Medicine, University of Melbourne, VIC, Australia
Issue Date: 16-Aug-2022
Date: 2022
Publication information: Occupational Medicine 2022; 72(6): 420-423
Abstract: Silicosis is a progressive and irreversible fibrotic occupational lung disease caused by inhalation of respirable crystalline silica (RCS). Recently, outbreaks have been reported in industries involving direct work with high silica-containing materials, such as artificial stone. Here, we describe an unexpected diagnosis made in an asymptomatic 33-year-old female worker employed for 4 years at a quarry for rhyodacite and rhyolite which contain 70% silicon dioxide. Chest computed tomography demonstrated small nodules in the upper lobes and larger ill-defined areas of opacity. Bronchoalveolar lavage revealed fine birefringent material within the cytoplasm of alveolar macrophages, representing silica. Transbronchial biopsies of lung parenchyma and endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal lymph nodes did not reveal features of sarcoidosis, tuberculosis, or malignancy. As such, a diagnosis of accelerated silicosis was confirmed and represents the first reported case in a female worker at a rhyodacite and rhyolite quarry.
DOI: 10.1093/occmed/kqac016
ORCID: 0000-0003-3727-5000
Journal: Occupational Medicine (Oxford, England)
PubMed URL: 35468208
PubMed URL:
Type: Journal Article
Subjects: occupational respiratory disease
Appears in Collections:Journal articles

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