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Title: Urodynamic findings in patients with nocturia and their associations with patient characteristics.
Austin Authors: Chan, Garson ;Qu, Liang G ;Gani, Johan 
Affiliation: Urology
Department of Urology, University of Melbourne, Western Health, Footscray, Victoria, Australia
Young Urology Researchers Organisation (YURO), Australia
Department of Urology, University of Saskatchewan, Saskatoon, SK, Canada
Issue Date: 11-Apr-2022
Date: 2022
Publication information: Canadian Urological Association Journal 2022;
Abstract: This study identified associations between lower urinary tract pathology confirmed on urodynamic testing, baseline characteristics, and symptoms for adults with nocturia. Nocturia frequency was examined for predictors. This retrospective study from 2012-2019 analyzed adult patients referred for urodynamic testing, with nocturia (waking to void ≥2x/night). Data on baseline characteristics, symptoms, urodynamic parameters, and lower urinary tract pathology were recorded. Males and females were analyzed separately, and univariable analyses were conducted, stratified by lower urinary tract pathology. Multivariable regression models were fit. Nocturia frequency was analyzed for associations with clinical parameters. Altogether, 372 patients were included (159 men and 213 women). More men had detrusor overactivity (DO) (p<0.001) and bladder outlet obstruction (BOO) (p<0.001). DO was associated with storage symptoms (odds ratio [OR] 5.19, p<0.001), in addition to older age (p=0.009) and being male (p<0.001). Detrusor underactivity (DU) was associated with voiding symptoms (OR 1.92, p=0.004), older age (p<0.001), and being female (p=0.018). BOO was associated voiding symptoms (OR 2.09, p=0.023), younger age (p=0.018), and being male (p<0.001). The quantity of lower urinary tract symptoms was associated with DU and DO. Nocturia frequency was not associated with baseline variables or underlying pathologies. A substantial number of patients were diagnosed with DU alone (n=69, 18.7%) or associated with other diagnoses (n=108, 29.3%). Careful assessment of risk factors and symptoms may help identify underlying lower urinary tract pathology for adults with nocturia. DU is found in a significant proportion of patients with nocturia, a previously under-reported result.
DOI: 10.5489/cuaj.7792
ORCID: 0000-0002-5710-1983
Journal: Canadian Urological Association journal = Journal de l'Association des Urologues du Canada
PubMed URL: 35426788
PubMed URL:
ISSN: 1911-6470
Type: Journal Article
Appears in Collections:Journal articles

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