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|Title:||Hemispheric cortical atrophy and chronic microglial activation following mild focal ischemic stroke in adult male rats.||Austin Authors:||Ermine, Charlotte M;Nithianantharajah, Jess;O'Brien, Katrina;Kauhausen, Jessica A;Frausin, Stefano;Oman, Alexander;Parsons, Mark W;Brait, Vanessa H;Brodtmann, Amy ;Thompson, Lachlan H||Affiliation:||Eastern Cognitive Disorders Clinic, Eastern Health, Monash University, Clayton, VIC, Australia..
The Florey Institute of Neuroscience and Mental Health
Melbourne Brain Centre, University of Melbourne, Melbourne, VIC, Australia..
Department of Neurology, University of New Wales South Western Clinical School, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia..
|Issue Date:||Dec-2021||metadata.dc.date:||2021||Publication information:||Journal of neuroscience research 2021; 99(12): 3222-3237||Abstract:||Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this research has focused on the acute phase following severe forms of stroke that result in clear behavioral deficits. Human stroke, however, can vary widely in severity and clinical outcome. There is a rapidly building body of work suggesting that milder ischemic insults can precipitate functional impairment, including cognitive decline, that continues through the chronic phase after injury. Here we show that a small infarction localized to the frontal motor cortex of rats following injection of endothelin-1 results in an essentially asymptomatic state based on motor and cognitive testing, and yet produces significant histopathological change including remote atrophy and inflammation that persists up to 1 year. While there is understandably a major focus in stroke research on mitigating the acute consequences of primary infarction, these results point to progressive atrophy and chronic inflammation as additional targets for intervention in the chronic phase after injury. The present rodent model provides an important platform for further work in this area.||URI:||https://ahro.austin.org.au/austinjspui/handle/1/29703||DOI:||10.1002/jnr.24939||ORCID:||0000-0003-4726-1120
|Journal:||Journal of neuroscience research||PubMed URL:||34651338||PubMed URL:||https://pubmed.ncbi.nlm.nih.gov/34651338/||Type:||Journal Article||Subjects:||RRID:AB_10711153
|Appears in Collections:||Journal articles|
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