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Title: Focal Epilepsy in Children With Tuberous Sclerosis Complex: Does Vigabatrin Control Focal Seizures?
Austin Authors: Lin, Sufang;Liao, Jianxiang;Zhao, Xia;Hu, Yan;Chen, Li;Chen, Yan;Liu, Guosheng;Yao, Yi;Su, Qiru;Scheffer, Ingrid E ;Wen, Feiqiu
Affiliation: University of Melbourne, Royal Children's Hospital, and Murdoch Institute, Melbourne, Australia..
Department of Pediatrics, The First Affiliated Hospital 162698Jinan University, Guangzhou, Guangdong, China..
Department of Neurology, 85113Shenzhen Children's Hospital, Shenzhen, Guangdong, China..
Department of Epilepsy Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..
Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..
Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..
Austin Health
The Florey Institute of Neuroscience and Mental Health
Issue Date: Apr-2022
Date: 2022-03-23
Publication information: Journal of Child Neurology 2022; 37(5): 329-333
Abstract: We evaluated the efficacy and safety of vigabatrin in focal epilepsy associated with tuberous sclerosis complex by retrospectively reviewing patients with focal epilepsy and tuberous sclerosis complex treated with vigabatrin at a pediatric epilepsy center over an 8-year period. Of 85 patients, 20 (23.5%) were seizure-free for >12 months, 45 (52.9%) were responders (≥50% seizure reduction), and 20 (23.5%) were nonresponders. The median age (in months) at seizure onset in the seizure-free group (median, 15; interquartile range [IQR], 6-23.3) was higher than that of responders (median, 5; IQR, 3-14) and nonresponders (median, 6; IQR, 2-12). Fewer patients in the seizure-free group had calcification in their largest tubers, but the presence of tuber calcification did not differ among groups. Vigabatrin is more likely to result in seizure freedom in children with tuberous sclerosis complex who have later infantile onset of focal seizures and no calcification in their largest tuber.
DOI: 10.1177/08830738211048326
Journal: Journal of child neurology
PubMed URL: 35321578
PubMed URL:
Type: Journal Article
Subjects: child
focal seizures
tuber calcification
tuberous sclerosis complex
Appears in Collections:Journal articles

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