Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/29611
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dc.contributor.authorLin, Sufang-
dc.contributor.authorLiao, Jianxiang-
dc.contributor.authorZhao, Xia-
dc.contributor.authorHu, Yan-
dc.contributor.authorChen, Li-
dc.contributor.authorChen, Yan-
dc.contributor.authorLiu, Guosheng-
dc.contributor.authorYao, Yi-
dc.contributor.authorSu, Qiru-
dc.contributor.authorScheffer, Ingrid E-
dc.contributor.authorWen, Feiqiu-
dc.date2022-03-23-
dc.date.accessioned2022-03-31T22:49:39Z-
dc.date.available2022-03-31T22:49:39Z-
dc.date.issued2022-04-
dc.identifier.citationJournal of Child Neurology 2022; 37(5): 329-333en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/29611-
dc.description.abstractWe evaluated the efficacy and safety of vigabatrin in focal epilepsy associated with tuberous sclerosis complex by retrospectively reviewing patients with focal epilepsy and tuberous sclerosis complex treated with vigabatrin at a pediatric epilepsy center over an 8-year period. Of 85 patients, 20 (23.5%) were seizure-free for >12 months, 45 (52.9%) were responders (≥50% seizure reduction), and 20 (23.5%) were nonresponders. The median age (in months) at seizure onset in the seizure-free group (median, 15; interquartile range [IQR], 6-23.3) was higher than that of responders (median, 5; IQR, 3-14) and nonresponders (median, 6; IQR, 2-12). Fewer patients in the seizure-free group had calcification in their largest tubers, but the presence of tuber calcification did not differ among groups. Vigabatrin is more likely to result in seizure freedom in children with tuberous sclerosis complex who have later infantile onset of focal seizures and no calcification in their largest tuber.en
dc.language.isoeng-
dc.subjectchilden
dc.subjectfocal seizuresen
dc.subjecttuber calcificationen
dc.subjecttuberous sclerosis complexen
dc.subjectvigabatrinen
dc.titleFocal Epilepsy in Children With Tuberous Sclerosis Complex: Does Vigabatrin Control Focal Seizures?en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of child neurologyen
dc.identifier.affiliationUniversity of Melbourne, Royal Children's Hospital, and Murdoch Institute, Melbourne, Australia..en
dc.identifier.affiliationDepartment of Pediatrics, The First Affiliated Hospital 162698Jinan University, Guangzhou, Guangdong, China..en
dc.identifier.affiliationDepartment of Neurology, 85113Shenzhen Children's Hospital, Shenzhen, Guangdong, China..en
dc.identifier.affiliationDepartment of Epilepsy Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..en
dc.identifier.affiliationInstitute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..en
dc.identifier.affiliationDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China..en
dc.identifier.affiliationAustin Healthen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35321578/en
dc.identifier.doi10.1177/08830738211048326en
dc.type.contentTexten
dc.identifier.orcidhttps://orcid.org/0000-0001-5728-1462en
dc.identifier.orcidhttps://orcid.org/0000-0002-2311-2174en
dc.identifier.pubmedid35321578-
local.name.researcherScheffer, Ingrid E
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
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