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Title: Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them.
Austin Authors: Dalton, Emily J;Churilov, Leonid ;Lannin, Natasha A;Corbett, Dale;Campbell, Bruce C V;Hayward, Kathryn S 
Affiliation: The Florey Institute of Neuroscience and Mental Health..
Medicine (University of Melbourne)..
Monash University, Melbourne, VIC, Australia..
Alfred Health, Melbourne, Australia..
University of Ottawa, Ottawa, Canada..
Melbourne Brain Centre, Royal Melbourne Hospital, Parkville, VIC, Australia..
Issue Date: Aug-2021
Date: 2021-06-04
Publication information: Neurorehabilitation and neural repair 2021; 35(8): 663-679
Abstract: Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajectory of recovery poststroke. We argue that early-phase research to systematically investigate dose is an important contributor to advance the science underpinning stroke recovery. In this article, we aim to (a) define the problem of insufficient use of a systematic approach to early-phase, multidimensional dose articulation research and (b) propose a solution that applies this approach to design a multidimensional phase I trial to identify the maximum tolerated dose (MTD). We put forward a design template as a decision support tool to increase knowledge of how to develop a phase I dose-ranging trial for nonpharmaceutical stroke recovery interventions. This solution has the potential to advance the development of efficacious stroke recovery interventions, which include activity-based rehabilitation interventions.
DOI: 10.1177/15459683211019362
ORCID: 0000-0003-3920-8530
Journal: Neurorehabilitation and neural repair
PubMed URL: 34085851
PubMed URL:
Type: Journal Article
Subjects: clinical trials
maximum tolerable dose
phase I
stroke rehabilitation
upper limb
Appears in Collections:Journal articles

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