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Title: Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.
Austin Authors: Kiewa, Jacqueline;Meltzer-Brody, Samantha;Milgrom, Jeanette;Guintivano, Jerry;Hickie, Ian B;Whiteman, David C;Olsen, Catherine M;Colodro-Conde, Lucía;Medland, Sarah E;Martin, Nicholas G;Wray, Naomi R;Byrne, Enda M
Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia..
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia..
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia..
Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia..
Parent-Infant Research Institute
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA..
Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia..
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia..
Issue Date: Mar-2022
Date: 2022
Publication information: Depression and Anxiety 2022; 39(3): 182-191
Abstract: Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD. Genes differentially expressed in ovarian tissue were significantly enriched (stdBeta = 0.07, p = 3.3e-04), but were not found to be associated with NPD. The genetic correlation between PND and MDD was 0.93 (SE = 0.07; p = 3.5e-38). Compared with controls, PGS for MDD are higher for PND cases (odds ratio [OR] = 1.8, confidence interval [CI] = [1.7-1.8], p = 9.5e-140) than for NPD cases (OR = 1.6, CI = [1.5-1.7], p = 1.2e-49). Highest risk is for those reporting both antenatal and postnatal depression, irrespective of prior MDD history. PND has a high genetic overlap with MDD, but points of distinction focus on differential expression in ovarian tissue and higher MDD PGS, particularly for women experiencing both antenatal and postpartum PND.
DOI: 10.1002/da.23232
Journal: Depression and Anxiety
PubMed URL: 34985809
PubMed URL:
Type: Journal Article
Subjects: depression
pregnancy and postpartum
Appears in Collections:Journal articles

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