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dc.contributor.authorKiewa, Jacqueline-
dc.contributor.authorMeltzer-Brody, Samantha-
dc.contributor.authorMilgrom, Jeanette-
dc.contributor.authorGuintivano, Jerry-
dc.contributor.authorHickie, Ian B-
dc.contributor.authorWhiteman, David C-
dc.contributor.authorOlsen, Catherine M-
dc.contributor.authorColodro-Conde, Lucía-
dc.contributor.authorMedland, Sarah E-
dc.contributor.authorMartin, Nicholas G-
dc.contributor.authorWray, Naomi R-
dc.contributor.authorByrne, Enda M-
dc.identifier.citationDepression and Anxiety 2022; 39(3): 182-191en
dc.description.abstractDistinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD. Genes differentially expressed in ovarian tissue were significantly enriched (stdBeta = 0.07, p = 3.3e-04), but were not found to be associated with NPD. The genetic correlation between PND and MDD was 0.93 (SE = 0.07; p = 3.5e-38). Compared with controls, PGS for MDD are higher for PND cases (odds ratio [OR] = 1.8, confidence interval [CI] = [1.7-1.8], p = 9.5e-140) than for NPD cases (OR = 1.6, CI = [1.5-1.7], p = 1.2e-49). Highest risk is for those reporting both antenatal and postnatal depression, irrespective of prior MDD history. PND has a high genetic overlap with MDD, but points of distinction focus on differential expression in ovarian tissue and higher MDD PGS, particularly for women experiencing both antenatal and postpartum PND.en
dc.subjectpregnancy and postpartumen
dc.titlePerinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.en
dc.typeJournal Articleen
dc.identifier.journaltitleDepression and Anxietyen
dc.identifier.affiliationQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia..en
dc.identifier.affiliationInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia..en
dc.identifier.affiliationMelbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationParent-Infant Research Instituteen
dc.identifier.affiliationDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA..en
dc.identifier.affiliationChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia..en
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item.openairetypeJournal Article-
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