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Title: Respiratory function and respiratory complications in spinal cord injury: protocol for a prospective, multicentre cohort study in high-income countries.
Austin Authors: Raab, Anja M;Brinkhof, Martin W G;Berlowitz, David J ;Postma, Karin;Gobets, David;Hirschfeld, Sven;Hopman, Maria T E;Huber, Burkhart;Hund-Georgiadis, Margret;Jordan, Xavier;Schubert, Martin;Wildburger, Renate;Mueller, Gabi
Affiliation: Institute for Breathing and Sleep
Clinical Trial Unit, Swiss Paraplegic Center, Nottwil, Switzerland
Department of Physiotherapy, University of Melbourne, Melbourne, Victoria, Australia
Life Course Epidemiology Group, Swiss Paraplegic Research, Nottwil, Switzerland
Department of Rehabilitation Medicine, Rijndam Rehabilitation and Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Rehabilitation Medicine, Heliomare Rehabilitation Center, Wijk aan Zee, The Netherlands
Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Trauma Surgery, AUVA Rehabilitation Center Häring, Bad Häring, Austria
Clinic for neurorehabilitation and paraplegiology, REHAB Basel, Basel, Switzerland
Spinal Cord Unit, Clinique romande de réadaptation, Sion, Switzerland
Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland
Allgemeine Unfallversicherungsanstalt, AUVA Rehabilitation Clinic Tobelbad, Tobelbad, Austria
Clinical Trial Unit, Swiss Paraplegic Center, Nottwil, Switzerland
Department of Spinal Cord Medicine, BG Trauma Hospital, Hamburg, Germany
Issue Date: 5-Nov-2020
Date: 2020
Publication information: BMJ open 2020; 10(11): e038204
Abstract: Pneumonia is one of the leading complications and causes of death after a spinal cord injury (SCI). After a cervical or thoracic lesion, impairment of the respiratory muscles decreases respiratory function, which increases the risk of respiratory complications. Pneumonia substantially reduces patient's quality of life, may prolong inpatient rehabilitation time, increase healthcare costs or at worse, lead to early death. Respiratory function and coughing can be improved through various interventions after SCI, but the available evidence as to which aspect of respiratory care should be optimised is inconclusive. Furthermore, ability of respiratory function parameters to predict pneumonia risk is insufficiently established. This paper details the protocol for a large-scale, multicentre research project that aims to evaluate the ability of parameters of respiratory function to predict and understand variation in inpatient risk of pneumonia in SCI. RESCOM, a prospective cohort study, began recruitment in October 2016 across 10 SCI rehabilitation centres from Australia, Austria, Germany, the Netherlands and Switzerland. Inpatients with acute SCI, with complete or incomplete cervical or thoracic lesions, 18 years or older and not/no more dependent on 24-hour mechanical ventilation within the first 3 months after injury are eligible for inclusion. The target sample size is 500 participants. The primary outcome is an occurrence of pneumonia; secondary outcomes include pneumonia-related mortality and quality of life. We will use the longitudinal data for prognostic models on inpatient pneumonia risk factors. The study has been reviewed and approved by all local ethics committees of all participating centres. Study results will be disseminated to the scientific community through peer-reviewed journals and conference presentations, to the SCI community, other stakeholders and via social media, newsletters and engagement activities. NCT02891096.
DOI: 10.1136/bmjopen-2020-038204
ORCID: 0000-0002-4139-2173
Journal: BMJ open
PubMed URL: 33154049
PubMed URL:
Type: Journal Article
Subjects: epidemiology
rehabilitation medicine
respiratory infections
Appears in Collections:Journal articles

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