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Title: Infant body mass index trajectories and asthma and lung function.
Austin Authors: Ali, Gulshan Bano;Bui, Dinh Son;Lodge, Caroline Jane;Waidyatillake, Nilakshi T;Perret, Jennifer L ;Sun, Cong;Walters, Eugene Haydn;Abramson, Michael John;Lowe, Adrian J;Dharmage, Shyamali Chandrika
Affiliation: Institute for Breathing and Sleep
School of Medicine, University of Tasmania, Tasmania, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia
Issue Date: Sep-2021 2021-03-01
Publication information: The Journal of Allergy and Clinical Immunology 2021; 148(3): 763-770
Abstract: The impact of early rapid increase in body mass index (BMI) on asthma risk and subsequent lung function remains contentious, with limited prospective studies during a critical window for lung growth. Our aim was to investigate the associations between BMI trajectories in the first 2 years of life and adolescent asthma and lung function. Anthropometric data on 620 infants from the Melbourne Atopy Cohort Study were collected up to 18 times in the first 24 months of the study. BMI trajectories were developed by using group-based trajectory modeling. Associations between these trajectories and spirometry, fractional exhaled nitric oxide level, and current asthma status at 12 and/or 18 years of age were modeled by using multiple linear and logistic regression. A total of 5 BMI trajectories were identified. Compared with those children with the "average" trajectory, the children belonging to the "early-low and catch-up" and "persistently high" BMI trajectories were at higher risk of asthma at the age of 18 years (odds ratios = 2.2 [95% CI = 1.0-4.8] and 2.4 [95% CI = 1.1-5.3], respectively). These trajectories were also associated with a lower ratio of FEV1 to forced vital capacity and a higher fractional exhaled nitric oxide levels at age 18 years. In addition, children belonging to the persistently low trajectory had lower FEV1 (β = -183.9 mL [95% CI = -340.9 to -26.9]) and forced vital capacity (β = -207.8 mL [95% CI = -393.6 to -22.0]) values at the age of 18 years. In this cohort, the early-low and catch-up and persistently high trajectories were associated with asthma and obstructive lung function pattern in adolescence. Having a persistently low BMI at an early age was associated with a restrictive pattern. Thus, maintenance of normal growth patterns may lead to improved adolescent respiratory health.
DOI: 10.1016/j.jaci.2021.02.020
ORCID: 0000-0001-7034-0615
Journal: The Journal of Allergy and Clinical Immunology
PubMed URL: 33662371
PubMed URL:
Type: Journal Article
Subjects: Infant body mass index
body mass index trajectories
early growth pattern
early rapid growth
group-based trajectory modeling
growth developmental trajectories
infant growth trajectories
lung function
Appears in Collections:Journal articles

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