Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28094
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dc.contributor.authorAli, Gulshan Bano-
dc.contributor.authorBui, Dinh Son-
dc.contributor.authorLodge, Caroline Jane-
dc.contributor.authorWaidyatillake, Nilakshi T-
dc.contributor.authorPerret, Jennifer L-
dc.contributor.authorSun, Cong-
dc.contributor.authorWalters, Eugene Haydn-
dc.contributor.authorAbramson, Michael John-
dc.contributor.authorLowe, Adrian J-
dc.contributor.authorDharmage, Shyamali Chandrika-
dc.date2021-03-01-
dc.date.accessioned2021-11-24T05:39:50Z-
dc.date.available2021-11-24T05:39:50Z-
dc.date.issued2021-09-
dc.identifier.citationThe Journal of Allergy and Clinical Immunology 2021; 148(3): 763-770en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28094-
dc.description.abstractThe impact of early rapid increase in body mass index (BMI) on asthma risk and subsequent lung function remains contentious, with limited prospective studies during a critical window for lung growth. Our aim was to investigate the associations between BMI trajectories in the first 2 years of life and adolescent asthma and lung function. Anthropometric data on 620 infants from the Melbourne Atopy Cohort Study were collected up to 18 times in the first 24 months of the study. BMI trajectories were developed by using group-based trajectory modeling. Associations between these trajectories and spirometry, fractional exhaled nitric oxide level, and current asthma status at 12 and/or 18 years of age were modeled by using multiple linear and logistic regression. A total of 5 BMI trajectories were identified. Compared with those children with the "average" trajectory, the children belonging to the "early-low and catch-up" and "persistently high" BMI trajectories were at higher risk of asthma at the age of 18 years (odds ratios = 2.2 [95% CI = 1.0-4.8] and 2.4 [95% CI = 1.1-5.3], respectively). These trajectories were also associated with a lower ratio of FEV1 to forced vital capacity and a higher fractional exhaled nitric oxide levels at age 18 years. In addition, children belonging to the persistently low trajectory had lower FEV1 (β = -183.9 mL [95% CI = -340.9 to -26.9]) and forced vital capacity (β = -207.8 mL [95% CI = -393.6 to -22.0]) values at the age of 18 years. In this cohort, the early-low and catch-up and persistently high trajectories were associated with asthma and obstructive lung function pattern in adolescence. Having a persistently low BMI at an early age was associated with a restrictive pattern. Thus, maintenance of normal growth patterns may lead to improved adolescent respiratory health.en
dc.language.isoeng
dc.subjectInfant body mass indexen
dc.subjectasthmaen
dc.subjectbody mass index trajectoriesen
dc.subjectearly growth patternen
dc.subjectearly rapid growthen
dc.subjectgroup-based trajectory modelingen
dc.subjectgrowth developmental trajectoriesen
dc.subjectinfant growth trajectoriesen
dc.subjectlung functionen
dc.titleInfant body mass index trajectories and asthma and lung function.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of Allergy and Clinical Immunologyen
dc.identifier.affiliationInstitute for Breathing and Sleepen
dc.identifier.affiliationSchool of Medicine, University of Tasmania, Tasmania, Australiaen
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australiaen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/33662371/en
dc.identifier.doi10.1016/j.jaci.2021.02.020en
dc.type.contentTexten
dc.identifier.orcid0000-0001-7034-0615en
dc.identifier.pubmedid33662371
local.name.researcherPerret, Jennifer L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
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