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Title: Clinical outcomes of patients with two small hepatocellular carcinomas.
Austin Authors: Pham, Anh Duy;Vaz, Karl;Ardalan, Zaid S;Sinclair, Marie ;Apostolov, Ross ;Gardner, Sarah;Majeed, Ammar;Mishra, Gauri;Kam, Ning Mao;Patwala, Kurvi;Kutaiba, Numan ;Arachchi, Niranjan;Bell, Sally;Dev, Anouk T;Lubel, John S;Nicoll, Amanda J;Sood, Siddharth ;Kemp, William;Roberts, Stuart K;Fink, Michael A ;Testro, Adam G ;Angus, Peter W ;Gow, Paul J 
Affiliation: Department of Gastroenterology, Alfred Health, Melbourne 3000, Victoria, Australia
Department of Gastroenterology and Hepatology, Monash Health, Clayton 3168, Victoria, Australia
The Melbourne Liver Group, Melbourne 3000, Victoria, Australia
Victorian Liver Transplant Unit
Issue Date: 27-Oct-2021
Publication information: World Journal of Hepatology 2021; 13(10): 1439-1449
Abstract: Management of single small hepatocellular carcinoma (HCC) is straightforward with curative outcomes achieved by locoregional therapy or resection. Liver transplantation is often considered for multiple small or single large HCC. Management of two small HCC whether presenting synchronously or sequentially is less clear. To define the outcomes of patients presenting with two small HCC. Retrospective review of HCC databases from multiple institutions of patients with either two synchronous or sequential HCC ≤ 3 cm between January 2000 and March 2018. Primary outcomes were overall survival (OS) and transplant-free survival (TFS). 104 patients were identified (male n = 89). Median age was 63 years (interquartile range 58-67.75) and the most common aetiology of liver disease was hepatitis C (40.4%). 59 (56.7%) had synchronous HCC and 45 (43.3%) had sequential. 36 patients died (34.6%) and 25 were transplanted (24.0%). 1, 3 and 5-year OS was 93.0%, 66.1% and 62.3% and 5-year post-transplant survival was 95.8%. 1, 3 and 5-year TFS was 82.1%, 45.85% and 37.8%. When synchronous and sequential groups were compared, OS (1,3 and 5 year synchronous 91.3%, 63.8%, 61.1%, sequential 95.3%, 69.5%, 64.6%, P = 0.41) was similar but TFS was higher in the sequential group (1,3 and 5 year synchronous 68.5%, 37.3% and 29.7%, sequential 93.2%, 56.6%, 48.5%, P = 0.02) though this difference did not remain during multivariate analysis. TFS in patients presenting with two HCC ≤ 3 cm is poor regardless of the timing of the second tumor. All patients presenting with two small HCC should be considered for transplantation.
DOI: 10.4254/wjh.v13.i10.1439
PubMed URL: 34786178
ISSN: 1948-5182
Type: Journal Article
Subjects: Hepatocellular carcinoma
Liver cancer
Transplant-free survival
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