Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27784
Title: Urinary biomarkers to predict severe fluid overload after cardiac surgery: a pilot study.
Austin Authors: Elitok, Saban;Isermann, Berend;Westphal, Sabine;Devarajan, Prasad;Albert, Christian;Kuppe, Hermann;Ernst, Martin;Bellomo, Rinaldo ;Haase, Michael;Haase-Fielitz, Anja
Affiliation: Institute of Social Medicine & Health Care Systems Research, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany
Diaverum Renal Care Center, Am Neuen Garten 11, 14469 Potsdam, Germany & Diaverum AB, Hyllie Boulevard 35, Malmö, 21532, Sweden
Department of Nephrology & Endocrinology, Ernst von Bergmann Hospital Potsdam, Charlottenstr. 72, Potsdam, 14467, Germany
Department of Cardiology, Brandenburg Heart Center, Immanuel Hospital, Ladeburger Str. 17, Bernau, 16321, Germany
Brandenburg Medical School Theodor Fontane, Fehrbelliner Str. 38, Neuruppin, 16816, Germany
Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany
Institute of Laboratory Medicine, Leipzig University Hospital, Paul-List-Str. 13/15, Leipzig, 04103, Germany
Institute of Laboratory Medicine, Tertiary Hospital Dessau, Auenweg 38, Dessau-Roßlau, 06847, Germany
Institute of Anesthesiology, German Heart Center, Augustenburger Platz 1, Berlin, 13353, Germany
Department of Nephrology & Hypertension, Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Medical Faculty, University Clinic for Cardiology & Angiology, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany
Medical Faculty, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany
Intensive Care
Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Australia
Issue Date: 2021
Date: 2021-10-21
Publication information: Biomarkers in medicine 2021; 15(16): 1451-1464
Abstract: Aim: To assess the predictive ability of urinary and plasma biomarkers and clinical routine parameters for subsequent severe fluid overload. Patients & methods: In a pilot study, we studied 100 adult patients after cardiac surgery. On intensive care unit admission, we measured biomarkers in urine (midkine, IL-6, neutrophil gelatinase-associated lipocalin [NGAL], hepcidin-25) and plasma (creatinine, urea, B-type natriuretic peptide, lactate, C-reactive protein, leukocytes, IL-6, NGAL, hepcidin-25) to predict postoperative severe fluid overload. Results: Urinary midkine, IL-6, NGAL and hepcidin-25 (all AUCs ≥0.79) predicted postoperative severe fluid overload (N = 5 patients). Urinary NGAL/hepcidin-25 ratio (AUC 0.867) predicted postoperative severe fluid overload after adjustment to EuroScore and need for norepinephrine on surgery day (odds ratio: 2.4). Conclusion: Urinary biomarkers on intensive care unit admission might be helpful to predict subsequent severe fluid overload after cardiac surgery.
URI: https://ahro.austin.org.au/austinjspui/handle/1/27784
DOI: 10.2217/bmm-2021-0283
ORCID: 0000-0002-1195-6871
0000-0003-0714-6160
0000-0002-5846-3345
0000-0002-7847-8552
0000-0002-6956-9962
0000-0003-3401-6935
0000-0002-1650-8939
0000-0001-8212-7416
0000-0001-6881-2249
Journal: Biomarkers in Medicine
PubMed URL: 34672680
Type: Journal Article
Subjects: IL-6
NGAL/hepcidin ratio
biomarker
cardiac surgery
cardiopulmonary bypass
cardiorenal syndrome
fluid overload
heart
kidney
midkine
Appears in Collections:Journal articles

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