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https://ahro.austin.org.au/austinjspui/handle/1/27784
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Elitok, Saban | - |
dc.contributor.author | Isermann, Berend | - |
dc.contributor.author | Westphal, Sabine | - |
dc.contributor.author | Devarajan, Prasad | - |
dc.contributor.author | Albert, Christian | - |
dc.contributor.author | Kuppe, Hermann | - |
dc.contributor.author | Ernst, Martin | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Haase, Michael | - |
dc.contributor.author | Haase-Fielitz, Anja | - |
dc.date | 2021-10-21 | - |
dc.date.accessioned | 2021-10-25T22:33:35Z | - |
dc.date.available | 2021-10-25T22:33:35Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Biomarkers in medicine 2021; 15(16): 1451-1464 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/27784 | - |
dc.description.abstract | Aim: To assess the predictive ability of urinary and plasma biomarkers and clinical routine parameters for subsequent severe fluid overload. Patients & methods: In a pilot study, we studied 100 adult patients after cardiac surgery. On intensive care unit admission, we measured biomarkers in urine (midkine, IL-6, neutrophil gelatinase-associated lipocalin [NGAL], hepcidin-25) and plasma (creatinine, urea, B-type natriuretic peptide, lactate, C-reactive protein, leukocytes, IL-6, NGAL, hepcidin-25) to predict postoperative severe fluid overload. Results: Urinary midkine, IL-6, NGAL and hepcidin-25 (all AUCs ≥0.79) predicted postoperative severe fluid overload (N = 5 patients). Urinary NGAL/hepcidin-25 ratio (AUC 0.867) predicted postoperative severe fluid overload after adjustment to EuroScore and need for norepinephrine on surgery day (odds ratio: 2.4). Conclusion: Urinary biomarkers on intensive care unit admission might be helpful to predict subsequent severe fluid overload after cardiac surgery. | en |
dc.language.iso | eng | - |
dc.subject | IL-6 | en |
dc.subject | NGAL/hepcidin ratio | en |
dc.subject | biomarker | en |
dc.subject | cardiac surgery | en |
dc.subject | cardiopulmonary bypass | en |
dc.subject | cardiorenal syndrome | en |
dc.subject | fluid overload | en |
dc.subject | heart | en |
dc.subject | kidney | en |
dc.subject | midkine | en |
dc.title | Urinary biomarkers to predict severe fluid overload after cardiac surgery: a pilot study. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Biomarkers in Medicine | en |
dc.identifier.affiliation | Institute of Social Medicine & Health Care Systems Research, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany | en |
dc.identifier.affiliation | Diaverum Renal Care Center, Am Neuen Garten 11, 14469 Potsdam, Germany & Diaverum AB, Hyllie Boulevard 35, Malmö, 21532, Sweden | en |
dc.identifier.affiliation | Department of Nephrology & Endocrinology, Ernst von Bergmann Hospital Potsdam, Charlottenstr. 72, Potsdam, 14467, Germany | en |
dc.identifier.affiliation | Department of Cardiology, Brandenburg Heart Center, Immanuel Hospital, Ladeburger Str. 17, Bernau, 16321, Germany | en |
dc.identifier.affiliation | Brandenburg Medical School Theodor Fontane, Fehrbelliner Str. 38, Neuruppin, 16816, Germany | en |
dc.identifier.affiliation | Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany | en |
dc.identifier.affiliation | Institute of Laboratory Medicine, Leipzig University Hospital, Paul-List-Str. 13/15, Leipzig, 04103, Germany | en |
dc.identifier.affiliation | Institute of Laboratory Medicine, Tertiary Hospital Dessau, Auenweg 38, Dessau-Roßlau, 06847, Germany | en |
dc.identifier.affiliation | Institute of Anesthesiology, German Heart Center, Augustenburger Platz 1, Berlin, 13353, Germany | en |
dc.identifier.affiliation | Department of Nephrology & Hypertension, Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA | en |
dc.identifier.affiliation | Medical Faculty, University Clinic for Cardiology & Angiology, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany | en |
dc.identifier.affiliation | Medical Faculty, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany | en |
dc.identifier.affiliation | Intensive Care | en |
dc.identifier.affiliation | Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Australia | en |
dc.identifier.doi | 10.2217/bmm-2021-0283 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-1195-6871 | en |
dc.identifier.orcid | 0000-0003-0714-6160 | en |
dc.identifier.orcid | 0000-0002-5846-3345 | en |
dc.identifier.orcid | 0000-0002-7847-8552 | en |
dc.identifier.orcid | 0000-0002-6956-9962 | en |
dc.identifier.orcid | 0000-0003-3401-6935 | en |
dc.identifier.orcid | 0000-0002-1650-8939 | en |
dc.identifier.orcid | 0000-0001-8212-7416 | en |
dc.identifier.orcid | 0000-0001-6881-2249 | en |
dc.identifier.pubmedid | 34672680 | - |
local.name.researcher | Bellomo, Rinaldo | |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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