Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.

2021-09

Gordon, Claire L

Smibert, Olivia C

Holmes, Natasha E

Chua, Kyra Y L

Rose, Morgan T

Drewett, George P

James, Fiona L

Mouhtouris, Effie

Nguyen, Thi H O

Zhang, Wuji

Kedzierski, Lukasz

Rowntree, Louise C

Chua, Brendon Y

Caly, Leon

Catton, Mike G

Druce, Julian

Sait, Michelle

Seemann, Torsten

Sherry, Norelle L

Howden, Benjamin P

Kedzierska, Katherine

Kwong, Jason C

Trubiano, Jason

COVID-19

SARS-CoV-2

cellular immunity

humoral immunity

immunocompromise

lymphoma

Journal Article

10.1093/ofid/ofab359

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR+/CD38+ activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2-specific antibody responses were absent and SARS-CoV-2-specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.

link

Open Forum Infectious Diseases 2021; 8(9): ofab359

Open Forum Infectious Diseases

2328-8957