Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27528
Title: Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication.
Austin Authors: Gordon, Claire L ;Smibert, Olivia C ;Holmes, Natasha E ;Chua, Kyra Y L ;Rose, Morgan T ;Drewett, George P ;James, Fiona L ;Mouhtouris, Effie ;Nguyen, Thi H O;Zhang, Wuji;Kedzierski, Lukasz;Rowntree, Louise C;Chua, Brendon Y;Caly, Leon;Catton, Mike G;Druce, Julian;Sait, Michelle;Seemann, Torsten;Sherry, Norelle L ;Howden, Benjamin P ;Kedzierska, Katherine;Kwong, Jason C ;Trubiano, Jason 
Affiliation: Medicine (University of Melbourne)
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Centre for Antibiotic Allergy and Research
Infectious Diseases
Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia
National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, Australia
Data Analytics Research and Evaluation Centre, Austin Health and University of Melbourne, Heidelberg, Victoria, Australia
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Issue Date: Sep-2021
Date: 2021-08-02
Publication information: Open Forum Infectious Diseases 2021; 8(9): ofab359
Abstract: We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR+/CD38+ activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2-specific antibody responses were absent and SARS-CoV-2-specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.
URI: https://ahro.austin.org.au/austinjspui/handle/1/27528
DOI: 10.1093/ofid/ofab359
Journal: Open Forum Infectious Diseases
PubMed URL: 34514016
ISSN: 2328-8957
Type: Journal Article
Subjects: COVID-19
SARS-CoV-2
cellular immunity
humoral immunity
immunocompromise
lymphoma
Appears in Collections:Journal articles

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