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Title: Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion.
Austin Authors: Pujari, Reshma;Newman, Marsali R ;Talia, Karen L;Pendlebury, Adam;Hawkes, David;Ireland-Jenkin, Kerryn ;McCluggage, W Glenn
Affiliation: Mercy Hospital for Women, Heidelberg, Victoria, Australia
VCS Pathology, VCS Foundation, Carlton, Victoria, Australia
Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom
Issue Date: 22-Jul-2021
Date: 2021
Publication information: Acta Cytologica 2021; 65(5): 448-452
Abstract: Seborrheic keratosis-like lesion of the cervix and vagina is a rare lesion and shows similar morphology to vulvar seborrheic keratosis; 3 of the 7 previously reported cases were associated with low-risk human papillomavirus (HPV) type 42. We report a case of seborrheic keratosis-like lesion of the cervix and provide the first description of the cytological features of this lesion. A woman in her late forties presented with postcoital bleeding. She had a cervical screening test following which she underwent cervical biopsy, endocervical and endometrial curettage, large loop excision of the transformation zone of the cervix, and hysterectomy. The liquid-based cytology preparation showed cohesive groups of mildly atypical squamoid cells with a spindle cell morphology, mildly increased nuclear to cytoplasmic ratio, prominent nucleoli, and occasional nuclear grooves. No koilocytes were identified. Molecular genotyping revealed positivity for HPV type 42. This represents the first description of the cytological features of a seborrheic keratosis-like lesion of the cervix, which are distinctive and unusual. Whilst the mild squamous atypia raised the possibility of a low-grade squamous intraepithelial lesion, no koilocytes were identified. The association in our case with a low-risk HPV type, HPV 42, provides further evidence for a role of this HPV type in the pathogenesis of these lesions.
DOI: 10.1159/000517479
Journal: Acta Cytologica
PubMed URL: 34293740
Type: Journal Article
Subjects: Cervical cytology
Human papillomavirus
Human papillomavirus type 42
Seborrheic keratosis-like lesion of the cervix
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