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Title: Potential gut-brain mechanisms behind adverse mental health outcomes of bariatric surgery.
Austin Authors: Brown, Robyn M;Guerrero-Hreins, Eva;Brown, Wendy A;le Roux, Carel W;Sumithran, Priya 
Affiliation: Endocrinology
Department of Biochemistry and Pharmacology, School of Biomedical Sciences, University of Melbourne, Parkville, Victoria, Australia
Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College, Dublin, Ireland
Department of Surgery, Central Clinical School, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
Department of Medicine (St Vincent's), University of Melbourne, Melbourne, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia
Issue Date: Sep-2021
Date: 2021-07-14
Publication information: Nature Reviews. Endocrinology 2021; 17(9): 549-559
Abstract: Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on the gut-brain axis that lead to alterations in the neuroendocrine regulation of appetite and glycaemia. However, in a subset of patients, bariatric surgery is associated with adverse effects on mental health, including increased risk of suicide or self-harm as well as the emergence of depression and substance use disorders. The contributing factors behind these adverse effects are not well understood. Accumulating evidence indicates that there are important links between gut-derived hormones, microbial and bile acid profiles, and disorders of mood and substance use, which warrant further exploration in the context of changes in gut-brain signalling after bariatric surgery. Understanding the basis of these adverse effects is essential in order to optimize the health and well-being of people undergoing treatment for obesity.
DOI: 10.1038/s41574-021-00520-2
ORCID: 0000-0001-5521-5445
Journal: Nature Reviews. Endocrinology
PubMed URL: 34262156
Type: Journal Article
Appears in Collections:Journal articles

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