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https://ahro.austin.org.au/austinjspui/handle/1/26741| Title: | Outcome after acute ischemic stroke is linked to sex-specific lesion patterns. | Austin Authors: | Bonkhoff, Anna K;Schirmer, Markus D;Bretzner, Martin;Hong, Sungmin;Regenhardt, Robert W;Brudfors, Mikael;Donahue, Kathleen L;Nardin, Marco J;Dalca, Adrian V;Giese, Anne-Katrin;Etherton, Mark R;Hancock, Brandon L;Mocking, Steven J T;McIntosh, Elissa C;Attia, John;Benavente, Oscar R;Bevan, Stephen;Cole, John W;Donatti, Amanda;Griessenauer, Christoph J;Heitsch, Laura;Holmegaard, Lukas;Jood, Katarina;Jimenez-Conde, Jordi;Kittner, Steven J;Lemmens, Robin;Levi, Christopher R;McDonough, Caitrin W;Meschia, James F;Phuah, Chia-Ling;Rolfs, Arndt;Ropele, Stefan;Rosand, Jonathan;Roquer, Jaume;Rundek, Tatjana;Sacco, Ralph L;Schmidt, Reinhold;Sharma, Pankaj;Slowik, Agnieszka;Söderholm, Martin;Sousa, Alessandro;Stanne, Tara M;Strbian, Daniel;Tatlisumak, Turgut;Thijs, Vincent N ;Vagal, Achala;Wasselius, Johan;Woo, Daniel;Zand, Ramin;McArdle, Patrick F;Worrall, Bradford B;Jern, Christina;Lindgren, Arne G;Maguire, Jane;Bzdok, Danilo;Wu, Ona;Rost, Natalia S | Affiliation: | Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany Univ. Lille, Inserm, CHU Lille, U1171 - LilNCog (JPARC) - Lille Neurosciences & Cognition, F-59000, Lille, France Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain St Peter's and Ashford Hospitals, Egham, UK School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK School of Life Sciences, University of Lincoln, Lincoln, UK Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Centogene AG, Rostock, Germany School of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, Sao Paulo, Brazil Department of Neurology, Skåne University Hospital, Lund and Malmö, Sweden Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, UK Department of clinical sciences Malmö, Lund University, Lund, Sweden Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden University of Technology Sydney, Sydney, NSW, Australia Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Neurology, Skåne University Hospital, Lund, Sweden Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University, Montreal, QC, Canada The Florey Institute of Neuroscience and Mental Health Neurology KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium VIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Department of Neurology, Leuven, Belgium.. School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, USA Department of Neurosurgery, Geisinger, Danville, PA, USA Research Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria Department of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Hunter Medical Research Institute, Newcastle, NSW, Australia Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA Department of Neurology, Geisinger, Danville, PA, USA Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL, USA Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital, St Louis, MO, USA Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA Mila - Quebec Artificial Intelligence Institute, Montreal, QC, Canada Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria Department of Neurology, Jagiellonian University Medical College, Krakow, Poland Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland |
Issue Date: | 2-Jun-2021 | Publication information: | Nature Communications 2021; 12(1): 3289 | Abstract: | Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/26741 | DOI: | 10.1038/s41467-021-23492-3 | ORCID: | 0000-0002-5927-1089 0000-0002-7594-4159 0000-0003-2958-3484 0000-0001-9800-1308 0000-0002-4475-8142 0000-0002-5559-768X 0000-0001-9095-2344 0000-0001-9386-4091 0000-0003-3466-6620 |
Journal: | Nature Communications | PubMed URL: | 34078897 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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