Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26741
Title: Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Austin Authors: Bonkhoff, Anna K;Schirmer, Markus D;Bretzner, Martin;Hong, Sungmin;Regenhardt, Robert W;Brudfors, Mikael;Donahue, Kathleen L;Nardin, Marco J;Dalca, Adrian V;Giese, Anne-Katrin;Etherton, Mark R;Hancock, Brandon L;Mocking, Steven J T;McIntosh, Elissa C;Attia, John;Benavente, Oscar R;Bevan, Stephen;Cole, John W;Donatti, Amanda;Griessenauer, Christoph J;Heitsch, Laura;Holmegaard, Lukas;Jood, Katarina;Jimenez-Conde, Jordi;Kittner, Steven J;Lemmens, Robin;Levi, Christopher R;McDonough, Caitrin W;Meschia, James F;Phuah, Chia-Ling;Rolfs, Arndt;Ropele, Stefan;Rosand, Jonathan;Roquer, Jaume;Rundek, Tatjana;Sacco, Ralph L;Schmidt, Reinhold;Sharma, Pankaj;Slowik, Agnieszka;Söderholm, Martin;Sousa, Alessandro;Stanne, Tara M;Strbian, Daniel;Tatlisumak, Turgut;Thijs, Vincent N ;Vagal, Achala;Wasselius, Johan;Woo, Daniel;Zand, Ramin;McArdle, Patrick F;Worrall, Bradford B;Jern, Christina;Lindgren, Arne G;Maguire, Jane;Bzdok, Danilo;Wu, Ona;Rost, Natalia S
Affiliation: Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany
Univ. Lille, Inserm, CHU Lille, U1171 - LilNCog (JPARC) - Lille Neurosciences & Cognition, F-59000, Lille, France
Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada
Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain
St Peter's and Ashford Hospitals, Egham, UK
School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK
School of Life Sciences, University of Lincoln, Lincoln, UK
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Centogene AG, Rostock, Germany
School of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, Sao Paulo, Brazil
Department of Neurology, Skåne University Hospital, Lund and Malmö, Sweden
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden
Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, UK
Department of clinical sciences Malmö, Lund University, Lund, Sweden
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
University of Technology Sydney, Sydney, NSW, Australia
Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden
Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Neurology, Skåne University Hospital, Lund, Sweden
Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University, Montreal, QC, Canada
The Florey Institute of Neuroscience and Mental Health
Neurology
KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
VIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Department of Neurology, Leuven, Belgium..
School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia
Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, USA
Department of Neurosurgery, Geisinger, Danville, PA, USA
Research Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria
Department of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Hunter Medical Research Institute, Newcastle, NSW, Australia
Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Department of Neurology, Geisinger, Danville, PA, USA
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL, USA
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital, St Louis, MO, USA
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Mila - Quebec Artificial Intelligence Institute, Montreal, QC, Canada
Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria
Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Issue Date: 2-Jun-2021
Publication information: Nature Communications 2021; 12(1): 3289
Abstract: Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26741
DOI: 10.1038/s41467-021-23492-3
ORCID: 0000-0002-5927-1089
0000-0002-7594-4159
0000-0003-2958-3484
0000-0001-9800-1308
0000-0002-4475-8142
0000-0002-5559-768X
0000-0001-9095-2344
0000-0001-9386-4091
0000-0003-3466-6620
Journal: Nature Communications
PubMed URL: 34078897
Type: Journal Article
Appears in Collections:Journal articles

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