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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26741
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dc.contributor.authorBonkhoff, Anna K-
dc.contributor.authorSchirmer, Markus D-
dc.contributor.authorBretzner, Martin-
dc.contributor.authorHong, Sungmin-
dc.contributor.authorRegenhardt, Robert W-
dc.contributor.authorBrudfors, Mikael-
dc.contributor.authorDonahue, Kathleen L-
dc.contributor.authorNardin, Marco J-
dc.contributor.authorDalca, Adrian V-
dc.contributor.authorGiese, Anne-Katrin-
dc.contributor.authorEtherton, Mark R-
dc.contributor.authorHancock, Brandon L-
dc.contributor.authorMocking, Steven J T-
dc.contributor.authorMcIntosh, Elissa C-
dc.contributor.authorAttia, John-
dc.contributor.authorBenavente, Oscar R-
dc.contributor.authorBevan, Stephen-
dc.contributor.authorCole, John W-
dc.contributor.authorDonatti, Amanda-
dc.contributor.authorGriessenauer, Christoph J-
dc.contributor.authorHeitsch, Laura-
dc.contributor.authorHolmegaard, Lukas-
dc.contributor.authorJood, Katarina-
dc.contributor.authorJimenez-Conde, Jordi-
dc.contributor.authorKittner, Steven J-
dc.contributor.authorLemmens, Robin-
dc.contributor.authorLevi, Christopher R-
dc.contributor.authorMcDonough, Caitrin W-
dc.contributor.authorMeschia, James F-
dc.contributor.authorPhuah, Chia-Ling-
dc.contributor.authorRolfs, Arndt-
dc.contributor.authorRopele, Stefan-
dc.contributor.authorRosand, Jonathan-
dc.contributor.authorRoquer, Jaume-
dc.contributor.authorRundek, Tatjana-
dc.contributor.authorSacco, Ralph L-
dc.contributor.authorSchmidt, Reinhold-
dc.contributor.authorSharma, Pankaj-
dc.contributor.authorSlowik, Agnieszka-
dc.contributor.authorSöderholm, Martin-
dc.contributor.authorSousa, Alessandro-
dc.contributor.authorStanne, Tara M-
dc.contributor.authorStrbian, Daniel-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorThijs, Vincent N-
dc.contributor.authorVagal, Achala-
dc.contributor.authorWasselius, Johan-
dc.contributor.authorWoo, Daniel-
dc.contributor.authorZand, Ramin-
dc.contributor.authorMcArdle, Patrick F-
dc.contributor.authorWorrall, Bradford B-
dc.contributor.authorJern, Christina-
dc.contributor.authorLindgren, Arne G-
dc.contributor.authorMaguire, Jane-
dc.contributor.authorBzdok, Danilo-
dc.contributor.authorWu, Ona-
dc.contributor.authorRost, Natalia S-
dc.date.accessioned2021-06-14T23:57:25Z-
dc.date.available2021-06-14T23:57:25Z-
dc.date.issued2021-06-02-
dc.identifier.citationNature Communications 2021; 12(1): 3289en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26741-
dc.description.abstractAcute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.en
dc.language.isoeng
dc.titleOutcome after acute ischemic stroke is linked to sex-specific lesion patterns.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature Communicationsen
dc.identifier.affiliationClinic for Neuroradiology, University Hospital Bonn, Bonn, Germanyen
dc.identifier.affiliationUniv. Lille, Inserm, CHU Lille, U1171 - LilNCog (JPARC) - Lille Neurosciences & Cognition, F-59000, Lille, Franceen
dc.identifier.affiliationDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canadaen
dc.identifier.affiliationDepartment of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spainen
dc.identifier.affiliationSt Peter's and Ashford Hospitals, Egham, UKen
dc.identifier.affiliationSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UKen
dc.identifier.affiliationSchool of Life Sciences, University of Lincoln, Lincoln, UKen
dc.identifier.affiliationDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germanyen
dc.identifier.affiliationCentogene AG, Rostock, Germanyen
dc.identifier.affiliationSchool of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, Sao Paulo, Brazilen
dc.identifier.affiliationDepartment of Neurology, Skåne University Hospital, Lund and Malmö, Swedenen
dc.identifier.affiliationDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Swedenen
dc.identifier.affiliationDepartment of Radiology, Neuroradiology, Skåne University Hospital, Lund, Swedenen
dc.identifier.affiliationDepartment of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Swedenen
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Neurology, Lund University, Lund, Swedenen
dc.identifier.affiliationJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAen
dc.identifier.affiliationAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USAen
dc.identifier.affiliationInstitute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, UKen
dc.identifier.affiliationDepartment of clinical sciences Malmö, Lund University, Lund, Swedenen
dc.identifier.affiliationDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Swedenen
dc.identifier.affiliationUniversity of Technology Sydney, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Radiology, Lund University, Lund, Swedenen
dc.identifier.affiliationDepartment of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Swedenen
dc.identifier.affiliationDepartment of Neurology, Skåne University Hospital, Lund, Swedenen
dc.identifier.affiliationDepartment of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University, Montreal, QC, Canadaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationNeurologyen
dc.identifier.affiliationKU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgiumen
dc.identifier.affiliationVIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Department of Neurology, Leuven, Belgium..en
dc.identifier.affiliationSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australiaen
dc.identifier.affiliationDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australiaen
dc.identifier.affiliationComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, USAen
dc.identifier.affiliationDepartment of Neurosurgery, Geisinger, Danville, PA, USAen
dc.identifier.affiliationResearch Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austriaen
dc.identifier.affiliationDepartment of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USAen
dc.identifier.affiliationDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Swedenen
dc.identifier.affiliationHunter Medical Research Institute, Newcastle, NSW, Australiaen
dc.identifier.affiliationDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USAen
dc.identifier.affiliationDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USAen
dc.identifier.affiliationDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USAen
dc.identifier.affiliationDepartment of Neurology, Geisinger, Danville, PA, USAen
dc.identifier.affiliationDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USAen
dc.identifier.affiliationDepartments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, USAen
dc.identifier.affiliationDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USAen
dc.identifier.affiliationDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL, USAen
dc.identifier.affiliationDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USAen
dc.identifier.affiliationDepartment of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital, St Louis, MO, USAen
dc.identifier.affiliationCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USAen
dc.identifier.affiliationMila - Quebec Artificial Intelligence Institute, Montreal, QC, Canadaen
dc.identifier.affiliationDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austriaen
dc.identifier.affiliationDepartment of Neurology, Jagiellonian University Medical College, Krakow, Polanden
dc.identifier.affiliationDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finlanden
dc.identifier.doi10.1038/s41467-021-23492-3en
dc.type.contentTexten
dc.identifier.orcid0000-0002-5927-1089en
dc.identifier.orcid0000-0002-7594-4159en
dc.identifier.orcid0000-0003-2958-3484en
dc.identifier.orcid0000-0001-9800-1308en
dc.identifier.orcid0000-0002-4475-8142en
dc.identifier.orcid0000-0002-5559-768Xen
dc.identifier.orcid0000-0001-9095-2344en
dc.identifier.orcid0000-0001-9386-4091en
dc.identifier.orcid0000-0003-3466-6620en
dc.identifier.pubmedid34078897
local.name.researcherThijs, Vincent N
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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