Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26622
Title: Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET.
Austin Authors: Song, Mengmeng;Beyer, Leonie;Kaiser, Lena;Barthel, Henryk;van Eimeren, Thilo;Marek, Ken;Nitschmann, Alexander;Scheifele, Maximilian;Palleis, Carla;Respondek, Gesine;Kern, Maike;Biechele, Gloria;Hammes, Jochen;Bischof, Gèrard;Barbe, Michael;Onur, Özgür;Jessen, Frank;Saur, Dorothee;Schroeter, Matthias L;Rumpf, Jost-Julian;Rullmann, Michael;Schildan, Andreas;Patt, Marianne;Neumaier, Bernd;Barret, Olivier;Madonia, Jennifer;Russell, David S;Stephens, Andrew W;Mueller, Andre;Roeber, Sigrun;Herms, Jochen;Bötzel, Kai;Danek, Adrian;Levin, Johannes;Classen, Joseph;Höglinger, Günter U;Bartenstein, Peter;Villemagne, Victor L ;Drzezga, Alexander;Seibyl, John;Sabri, Osama;Boening, Guido;Ziegler, Sibylle;Brendel, Matthias
Affiliation: Medicine (University of Melbourne)
Department of Psychiatry, University Hospital Cologne, Cologne, Germany
Center for Memory Disorders, University Hospital Cologne, Cologne, Germany
Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany
LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Max- Planck-Institute of Human Cognitive and Brain Sciences, Leipzig, Germany
FTLD Consortium Germany, Ulm, Germany
Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany
Molecular Neuroimaging, A Division of inviCRO, New Haven, CT, USA
Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, MIRCen, Fontenay-aux-Roses, France
Center for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany..
Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
Department of Neurology, Technical University Munich, Munich, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany..
Department of Neurology, University Hospital Cologne, Cologne, Germany
Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
InviCRO, LLC, Boston, MA, USA
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany
Department of Neurology, University Hospital Cologne, Cologne, Germany
Department of Neurology, University of Leipzig, Leipzig, Germany
Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
Life Molecular Imaging GmbH, Berlin, Germany
Center for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Neurology, University of Leipzig, Leipzig, Germany
Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Issue Date: 27-May-2021
metadata.dc.date: 2021-05-27
Publication information: Journal of Cerebral Blood Flow and Metabolism 2021; online first: 27 May
Abstract: The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26622
DOI: 10.1177/0271678X211018904
ORCID: 0000-0003-4247-184X
0000-0002-9105-2943
0000-0001-8857-5383
0000-0002-9247-2843
PubMed URL: 34044665
Type: Journal Article
Subjects: PI-2620
Tau
affinity
binding
kinetic modelling
Appears in Collections:Journal articles

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