Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26622
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dc.contributor.authorSong, Mengmeng-
dc.contributor.authorBeyer, Leonie-
dc.contributor.authorKaiser, Lena-
dc.contributor.authorBarthel, Henryk-
dc.contributor.authorvan Eimeren, Thilo-
dc.contributor.authorMarek, Ken-
dc.contributor.authorNitschmann, Alexander-
dc.contributor.authorScheifele, Maximilian-
dc.contributor.authorPalleis, Carla-
dc.contributor.authorRespondek, Gesine-
dc.contributor.authorKern, Maike-
dc.contributor.authorBiechele, Gloria-
dc.contributor.authorHammes, Jochen-
dc.contributor.authorBischof, Gèrard-
dc.contributor.authorBarbe, Michael-
dc.contributor.authorOnur, Özgür-
dc.contributor.authorJessen, Frank-
dc.contributor.authorSaur, Dorothee-
dc.contributor.authorSchroeter, Matthias L-
dc.contributor.authorRumpf, Jost-Julian-
dc.contributor.authorRullmann, Michael-
dc.contributor.authorSchildan, Andreas-
dc.contributor.authorPatt, Marianne-
dc.contributor.authorNeumaier, Bernd-
dc.contributor.authorBarret, Olivier-
dc.contributor.authorMadonia, Jennifer-
dc.contributor.authorRussell, David S-
dc.contributor.authorStephens, Andrew W-
dc.contributor.authorMueller, Andre-
dc.contributor.authorRoeber, Sigrun-
dc.contributor.authorHerms, Jochen-
dc.contributor.authorBötzel, Kai-
dc.contributor.authorDanek, Adrian-
dc.contributor.authorLevin, Johannes-
dc.contributor.authorClassen, Joseph-
dc.contributor.authorHöglinger, Günter U-
dc.contributor.authorBartenstein, Peter-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorDrzezga, Alexander-
dc.contributor.authorSeibyl, John-
dc.contributor.authorSabri, Osama-
dc.contributor.authorBoening, Guido-
dc.contributor.authorZiegler, Sibylle-
dc.contributor.authorBrendel, Matthias-
dc.date2021-05-27-
dc.date.accessioned2021-05-31T22:59:07Z-
dc.date.available2021-05-31T22:59:07Z-
dc.date.issued2021-05-27-
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism 2021; online first: 27 Mayen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26622-
dc.description.abstractThe novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.en
dc.language.isoeng
dc.subjectPI-2620en
dc.subjectTauen
dc.subjectaffinityen
dc.subjectbindingen
dc.subjectkinetic modellingen
dc.titleBinding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Cerebral Blood Flow and Metabolismen
dc.identifier.affiliationMunich Cluster for Systems Neurology (SyNergy), Munich, Germanyen
dc.identifier.affiliationGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germanyen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationDepartment of Psychiatry, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationCenter for Memory Disorders, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationClinic for Cognitive Neurology, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationMax- Planck-Institute of Human Cognitive and Brain Sciences, Leipzig, Germanyen
dc.identifier.affiliationFTLD Consortium Germany, Ulm, Germanyen
dc.identifier.affiliationCognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationMolecular Neuroimaging, A Division of inviCRO, New Haven, CT, USAen
dc.identifier.affiliationLaboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, MIRCen, Fontenay-aux-Roses, Franceen
dc.identifier.affiliationCenter for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, Medizinische Hochschule Hannover, Hannover, Germanyen
dc.identifier.affiliationDepartment of Neurology, Technical University Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationInviCRO, LLC, Boston, MA, USAen
dc.identifier.affiliationGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, Medizinische Hochschule Hannover, Hannover, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Neurology, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationLife Molecular Imaging GmbH, Berlin, Germanyen
dc.identifier.affiliationCenter for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.doi10.1177/0271678X211018904en
dc.type.contentTexten
dc.identifier.orcid0000-0003-4247-184Xen
dc.identifier.orcid0000-0002-9105-2943en
dc.identifier.orcid0000-0001-8857-5383en
dc.identifier.orcid0000-0002-9247-2843en
dc.identifier.pubmedid34044665
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