Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26617
Title: Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians.
Austin Authors: Watts, Gerald F;Sullivan, David R;Hare, David L ;Kostner, Karam M;Horton, Ari E;Bell, Damon A;Brett, Tom;Trent, Ronald J;Poplawski, Nicola K;Martin, Andrew C;Srinivasan, Shubha;Justo, Robert N;Chow, Clara K;Pang, Jing
Affiliation: School of Medicine, University of Queensland, Brisbane, Queensland, Australia
Cardiology
Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Department of Paediatric Cardiology, Queensland Children's Hospital, Brisbane, Queensland, Australia
School of Medicine, University of Western Australia, Perth, Western Australia, Australia
Lipid Disorders Clinic, Cardiometabolic Service, Departments of Cardiology and Internal Medicine, Royal Perth Hospital, Perth, Western Australia, Australia
Department of Chemical Pathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Department of Cardiology, Mater Hospital, University of Queensland, Brisbane, Queensland, Australia
Monash Heart and Monash Children's Hospital, Monash Health, Melbourne, Victoria, Australia
Monash Cardiovascular Research Centre, Melbourne, Victoria, Australia
Department of Paediatrics, Monash University, Melbourne, Victoria, Australia
Department of Clinical Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital and Fiona Stanley Hospital Network, Perth, Western Australia, Australia
Department of Clinical Biochemistry, Clinipath Pathology, Perth, Western Australia, Australia
Sonic Genetics, Sonic Pathology, Sydney, New South Wales, Australia
General Practice and Primary Health Care Research, School of Medicine, University of Notre Dame Australia, Perth, Western Australia, Australia
Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Department General Paediatrics, Perth Children's Hospital, Perth, Western Australia, Australia
Division of Paediatrics, University of Western Australia, Perth, Western Australia, Australia
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia
Discipline of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Westmead Applied Research Centre, The University of Sydney, Sydney, New South Wales, Australia
Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia
George Institute for Global Health, Sydney, New South Wales, Australia
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: May-2021
Date: 2021-05
Publication information: Internal Medicine Journal 2021; 51(5): 769-779
Abstract: Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors and appropriate use of low-density lipoprotein (LDL)-cholesterol-lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared decision-making with patients and families. New government-funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of the recommendations. However, a comprehensive implementation science and practice strategy is required to ensure that the guidance translates into benefit for all families with FH.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26617
DOI: 10.1111/imj.15327
ORCID: 0000-0003-2276-1524
0000-0002-9700-6948
Journal: Internal Medicine Journal
PubMed URL: 34047032
Type: Journal Article
Subjects: adults
care
familial hypercholesterolaemia
guidance
management
prevention
Appears in Collections:Journal articles

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