Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26545
Title: Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy.
Austin Authors: Song, Mengmeng;Scheifele, Maximilian;Barthel, Henryk;van Eimeren, Thilo;Beyer, Leonie;Marek, Ken;Eckenweber, Florian;Palleis, Carla;Kaiser, Lena;Finze, Anika;Kern, Maike;Nitschmann, Alexander;Biechele, Gloria;Katzdobler, Sabrina;Bischof, Gèrard;Hammes, Jochen;Jessen, Frank;Saur, Dorothee;Schroeter, Matthias L;Rumpf, Jost-Julian;Rullmann, Michael;Schildan, Andreas;Patt, Marianne;Neumaier, Bernd;Stephens, Andrew W;Rauchmann, Boris-Stephan;Perneczky, Robert;Levin, Johannes;Classen, Joseph;Höglinger, Günter U;Bartenstein, Peter;Boening, Guido;Ziegler, Sibylle;Villemagne, Victor L ;Drzezga, Alexander;Seibyl, John;Sabri, Osama;Brendel, Matthias
Affiliation: Molecular Neuroimaging, A Division of inviCRO, New Haven, CT, USA
Molecular Imaging and Therapy
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
General Medicine
Department of Neurology, University Hospital Leipzig, Leipzig, Germany
InviCRO, LLC, Boston, MA, USA
Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany
Department of Neurology, University Hospital Cologne, Cologne, Germany
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Radiologische Allianz, Nuklearmedizin Spitalerhof, Hamburg, Germany
Department of Psychiatry, University Hospital Cologne, Cologne, Germany
Center for Memory Disorders, University Hospital Cologne, Cologne, Germany
Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany
LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Max- Planck-Institute of Human Cognitive and Brain Sciences, Leipzig, Germany
Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany
Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Department of Radiology, University Hospital of Munich, LMU, Munich, Germany
Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College, London, UK
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany
Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany
Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany
Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
Life Molecular Imaging GmbH, Berlin, Germany
Issue Date: 22-May-2021
metadata.dc.date: 2021
Publication information: European Journal of Nuclear Medicine and Molecular Imaging 2021; online first: 22 May
Abstract: Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [18F]PI-2620 tau-PET imaging of PSP. Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [18F]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier). 0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%. Truncated and static imaging windows can be used for [18F]PI-2620 PET imaging of PSP. 0-40 min dynamic scanning offers the best balance between accuracy and economic scanning.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26545
DOI: 10.1007/s00259-021-05391-3
ORCID: 0000-0002-9247-2843
PubMed URL: 34021393
Type: Journal Article
Subjects: Progressive supranuclear palsy
Tau-PET
Time window
[18F]PI-2620
Appears in Collections:Journal articles

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