Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26545
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dc.contributor.authorSong, Mengmeng-
dc.contributor.authorScheifele, Maximilian-
dc.contributor.authorBarthel, Henryk-
dc.contributor.authorvan Eimeren, Thilo-
dc.contributor.authorBeyer, Leonie-
dc.contributor.authorMarek, Ken-
dc.contributor.authorEckenweber, Florian-
dc.contributor.authorPalleis, Carla-
dc.contributor.authorKaiser, Lena-
dc.contributor.authorFinze, Anika-
dc.contributor.authorKern, Maike-
dc.contributor.authorNitschmann, Alexander-
dc.contributor.authorBiechele, Gloria-
dc.contributor.authorKatzdobler, Sabrina-
dc.contributor.authorBischof, Gèrard-
dc.contributor.authorHammes, Jochen-
dc.contributor.authorJessen, Frank-
dc.contributor.authorSaur, Dorothee-
dc.contributor.authorSchroeter, Matthias L-
dc.contributor.authorRumpf, Jost-Julian-
dc.contributor.authorRullmann, Michael-
dc.contributor.authorSchildan, Andreas-
dc.contributor.authorPatt, Marianne-
dc.contributor.authorNeumaier, Bernd-
dc.contributor.authorStephens, Andrew W-
dc.contributor.authorRauchmann, Boris-Stephan-
dc.contributor.authorPerneczky, Robert-
dc.contributor.authorLevin, Johannes-
dc.contributor.authorClassen, Joseph-
dc.contributor.authorHöglinger, Günter U-
dc.contributor.authorBartenstein, Peter-
dc.contributor.authorBoening, Guido-
dc.contributor.authorZiegler, Sibylle-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorDrzezga, Alexander-
dc.contributor.authorSeibyl, John-
dc.contributor.authorSabri, Osama-
dc.contributor.authorBrendel, Matthias-
dc.date2021-
dc.date.accessioned2021-05-24T05:44:57Z-
dc.date.available2021-05-24T05:44:57Z-
dc.date.issued2021-05-22-
dc.identifier.citationEuropean Journal of Nuclear Medicine and Molecular Imaging 2021; online first: 22 Mayen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26545-
dc.description.abstractDynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [18F]PI-2620 tau-PET imaging of PSP. Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [18F]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier). 0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%. Truncated and static imaging windows can be used for [18F]PI-2620 PET imaging of PSP. 0-40 min dynamic scanning offers the best balance between accuracy and economic scanning.en
dc.language.isoeng
dc.subjectProgressive supranuclear palsyen
dc.subjectTau-PETen
dc.subjectTime windowen
dc.subject[18F]PI-2620en
dc.titleFeasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Nuclear Medicine and Molecular Imagingen
dc.identifier.affiliationMolecular Neuroimaging, A Division of inviCRO, New Haven, CT, USAen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USAen
dc.identifier.affiliationGeneral Medicineen
dc.identifier.affiliationDepartment of Neurology, University Hospital Leipzig, Leipzig, Germanyen
dc.identifier.affiliationInviCRO, LLC, Boston, MA, USAen
dc.identifier.affiliationCognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germanyen
dc.identifier.affiliationRadiologische Allianz, Nuklearmedizin Spitalerhof, Hamburg, Germanyen
dc.identifier.affiliationDepartment of Psychiatry, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationCenter for Memory Disorders, University Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationClinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germanyen
dc.identifier.affiliationLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germanyen
dc.identifier.affiliationMax- Planck-Institute of Human Cognitive and Brain Sciences, Leipzig, Germanyen
dc.identifier.affiliationInstitute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germanyen
dc.identifier.affiliationInstitute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Radiology, University Hospital of Munich, LMU, Munich, Germanyen
dc.identifier.affiliationAgeing Epidemiology Research Unit (AGE), School of Public Health, Imperial College, London, UKen
dc.identifier.affiliationGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germanyen
dc.identifier.affiliationMunich Cluster for Systems Neurology (SyNergy), Munich, Germanyen
dc.identifier.affiliationDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germanyen
dc.identifier.affiliationDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germanyen
dc.identifier.affiliationDepartment of Neurology, Medizinische Hochschule Hannover, Hannover, Germanyen
dc.identifier.affiliationLife Molecular Imaging GmbH, Berlin, Germanyen
dc.identifier.doi10.1007/s00259-021-05391-3en
dc.type.contentTexten
dc.identifier.orcid0000-0002-9247-2843en
dc.identifier.pubmedid34021393
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