Please use this identifier to cite or link to this item:
Title: Successful use of azithromycin for Escherichia coli-associated renal allograft malakoplakia: a report of two cases.
Austin Authors: Kinsella, Paul M;Smibert, Olivia C ;Whitlam, John B ;Steven, Mark;Masia, Ricard;Gandhi, Ronak G;Kotton, Camille N;Holmes, Natasha E 
Affiliation: Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA
Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA
Department of Pharmacy, Massachusetts General Hospital, Boston, MA, 02114, USA
Infectious Diseases
Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, 3010, Australia
Issue Date: Dec-2021
Date: 2021-05-14
Publication information: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2021-12; 40(12): 2627-2631
Abstract: Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal approach to therapy includes antimicrobials with intracellular activity, reduction in immunosuppression, and debulking of lesions. Azithromycin has an intracellular mechanism of action and enhanced Gram-negative activity compared to other macrolides. Despite some in vitro data to support its use, there are no clinical breakpoints or epidemiological cut-off values for most Enterobacterales from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) or the Clinical and Laboratory Standards Institute (CLSI). We present two cases, previously unreported, of Escherichia coli associated renal allograft malakoplakia successfully treated with azithromycin.
DOI: 10.1007/s10096-021-04270-x
ORCID: 0000-0002-6167-9366
Journal: European Journal of Clinical Microbiology & Infectious Diseases
PubMed URL: 33990891
Type: Journal Article
Subjects: Enterobacterales
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Dec 7, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.