Please use this identifier to cite or link to this item:
Title: Longitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults.
Austin Authors: Gardener, Samantha L;Weinborn, Michael;Sohrabi, Hamid R;Doecke, James D;Bourgeat, Pierrick;Rainey-Smith, Stephanie R;Shen, Kai-Kai;Fripp, Jurgen;Taddei, Kevin;Maruff, Paul;Salvado, Olivier;Savage, Greg;Ames, David;Masters, Colin L ;Rowe, Christopher C ;Martins, Ralph N
Affiliation: Florey Department of the University of Melbourne
Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia
ARC Centre of Excellence in Cognition and its Disorders and Department of Psychology, Macquarie University, New South Wales, Australia
CSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australia
CogState, Ltd., Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Molecular Imaging and Therapy
Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia
Department of Biomedical Sciences, Macquarie University, New South Wales, Australia
Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia
National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia
Issue Date: 2021 2021-04-27
Publication information: Journal of Alzheimer's Disease : JAD 2021; 81(3): 1039-1052
Abstract: Previous research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable. Preservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years. Regions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed by a discovery phase analyses of additional regions. SCPs were aged 70 + at baseline, scoring at/above normative memory (CVLT-II) levels for demographically similar individuals aged 30-44 years old, and in the unimpaired range for all other cognitive domains over the course of the study. In linear mixed models, following adjustment for multiple comparisons, there were no significant differences between rates of thinning or volume atrophy between SCPs and TOAs in previously identified ROIs, or the discovery phase analyses. With only amyloid-β negative individuals in the analyses, again there were no significant differences between SCPs and TOAs. The increased methodological rigor in classifying groups, together with the influence of cognitive reserve, are discussed as potential factors accounting for our findings as compared to the extant literature on those with superior cognitive performance for their age.
DOI: 10.3233/JAD-201243
PubMed URL: 33935071
Type: Journal Article
Subjects: Cognitive aging
cerebral volume atrophy
cortical thickness
cortical thinning
older adult superior cognitive performance
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Oct 1, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.