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dc.contributor.authorGardener, Samantha L-
dc.contributor.authorWeinborn, Michael-
dc.contributor.authorSohrabi, Hamid R-
dc.contributor.authorDoecke, James D-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorShen, Kai-Kai-
dc.contributor.authorFripp, Jurgen-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorSavage, Greg-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMartins, Ralph N-
dc.identifier.citationJournal of Alzheimer's Disease : JAD 2021; online first: 27 Aprilen
dc.description.abstractPrevious research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable. Preservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years. Regions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed by a discovery phase analyses of additional regions. SCPs were aged 70 + at baseline, scoring at/above normative memory (CVLT-II) levels for demographically similar individuals aged 30-44 years old, and in the unimpaired range for all other cognitive domains over the course of the study. In linear mixed models, following adjustment for multiple comparisons, there were no significant differences between rates of thinning or volume atrophy between SCPs and TOAs in previously identified ROIs, or the discovery phase analyses. With only amyloid-β negative individuals in the analyses, again there were no significant differences between SCPs and TOAs. The increased methodological rigor in classifying groups, together with the influence of cognitive reserve, are discussed as potential factors accounting for our findings as compared to the extant literature on those with superior cognitive performance for their age.en
dc.subjectCognitive agingen
dc.subjectcerebral volume atrophyen
dc.subjectcortical thicknessen
dc.subjectcortical thinningen
dc.subjectolder adult superior cognitive performanceen
dc.titleLongitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's Disease : JADen
dc.identifier.affiliationFlorey Department of the University of Melbourneen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationARC Centre of Excellence in Cognition and its Disorders and Department of Psychology, Macquarie University, New South Wales, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australiaen
dc.identifier.affiliationCogState, Ltd., Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationAustralian Alzheimer's Research Foundation, Perth, Western Australia, Australiaen
dc.identifier.affiliationSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australiaen
dc.identifier.affiliationCollege of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Biomedical Sciences, Macquarie University, New South Wales, Australiaen
dc.identifier.affiliationCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australiaen
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