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Title: SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults.
Austin Authors: Fernandez, Shane;Burnham, Samantha C;Milicic, Lidija;Savage, Greg;Maruff, Paul;Peretti, Madeline;Sohrabi, Hamid R;Lim, Yen Ying;Weinborn, Michael;Ames, David;Masters, Colin L ;Martins, Ralph N;Rainey-Smith, Stephanie;Rowe, Christopher C ;Salvado, Olivier;Groth, David;Verdile, Giuseppe;Villemagne, Victor L ;Porter, Tenielle;Laws, Simon M
Affiliation: School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia
ARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Macquarie University, North Ryde, NSW, Australia
Australian Alzheimer's Research Foundation, Nedlands, Western Australia
Collaborative Genomics and Translation Group, Center for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
CogState Ltd., Melbourne, Victoria, Australia
CSIRO Health and Biosecurity, Parkville, Victoria, Australia
Molecular Imaging and Therapy
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia
Medicine (University of Melbourne)
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia
Issue Date: 24-Feb-2021 2021-02-24
Publication information: Journal of Alzheimer's Disease Reports 2021; 5(1): 111-120
Abstract: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. The aim of this study was to assess whether the association was present in cognitively normal older adults. Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE)ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOEɛ4/rs11023139-A carriers declined significantly faster than APOEɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020). These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOEɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.
DOI: 10.3233/ADR-200246
Journal: Journal of Alzheimer's Disease Reports
PubMed URL: 33782664
Type: Journal Article
Subjects: APOE
Alzheimer’s disease
cognitive decline
Appears in Collections:Journal articles

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