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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26176
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dc.contributor.authorFernandez, Shane-
dc.contributor.authorBurnham, Samantha C-
dc.contributor.authorMilicic, Lidija-
dc.contributor.authorSavage, Greg-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorPeretti, Madeline-
dc.contributor.authorSohrabi, Hamid R-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorWeinborn, Michael-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorRainey-Smith, Stephanie-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorGroth, David-
dc.contributor.authorVerdile, Giuseppe-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorPorter, Tenielle-
dc.contributor.authorLaws, Simon M-
dc.date2021-02-24-
dc.date.accessioned2021-04-08T02:43:49Z-
dc.date.available2021-04-08T02:43:49Z-
dc.date.issued2021-02-24-
dc.identifier.citationJournal of Alzheimer's Disease Reports 2021; 5(1): 111-120en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26176-
dc.description.abstractGenetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. The aim of this study was to assess whether the association was present in cognitively normal older adults. Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE)ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOEɛ4/rs11023139-A carriers declined significantly faster than APOEɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020). These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOEɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.en
dc.language.isoeng-
dc.subjectAPOEen
dc.subjectAlzheimer’s diseaseen
dc.subjectSPON1en
dc.subjectSpondin-1en
dc.subjectamyloid-βen
dc.subjectcognitive declineen
dc.titleSPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's Disease Reportsen
dc.identifier.affiliationSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationCentre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Macquarie University, North Ryde, NSW, Australiaen
dc.identifier.affiliationAustralian Alzheimer's Research Foundation, Nedlands, Western Australiaen
dc.identifier.affiliationCollaborative Genomics and Translation Group, Center for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationCogState Ltd., Melbourne, Victoria, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity, Parkville, Victoria, Australiaen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australiaen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australiaen
dc.identifier.doi10.3233/ADR-200246en
dc.type.contentTexten
dc.identifier.pubmedid33782664-
local.name.researcherMasters, Colin L
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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