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Title: Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV.
Austin Authors: Lake, Jordan E;Trevillyan, Janine 
Affiliation: Division of Infectious Diseases, University of Texas Health Science Center, Houston, Texas, USA
Infectious Diseases
Issue Date: 1-May-2021
Date: 2021-03-31
Publication information: Current Opinion in HIV and AIDS 2021; 16(3): 148-151
Abstract: Obesity is increasing in people with HIV (PWH). This review aims to summarise the recent evidence investigating the associations between the use of integrase inhibitors and tenofovir alafenamide (TAF) with weight gain and the mechanisms by which this may occur. Understanding the role that antiretroviral therapies play in promoting weight gain is critical in making informed treatment decisions. Weight gain is common with antiretroviral therapies and can lead to significant medical complications for PWH. Antiretroviral regimens containing an integrase inhibitor in conjunction with TAF are associated with the greatest degree of weight gain. This weight gain is greatest with dolutegravir and bictegravir compared with other integrase inhibitors. Some of the measured weight gain attributed to TAF may actually reflect a loss of weight suppressant effects of tenofovir disoproxil fumarate, and thus the exact proportional contribution of TAF remains to be seen. The mechanisms by which advent of antiretroviral therapy may be promoting weight gain is still being determined but underlying genetic risks factors and gender are very important determinants of the degree of weight gained. Integrase inhibitors and TAF contribute to weight gain in PWH. This places them at risk for potentially serious medical complications.
DOI: 10.1097/COH.0000000000000680
Journal: Current Opinion in HIV and AIDS
PubMed URL: 33797433
Type: Journal Article
Appears in Collections:Journal articles

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