Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26136
Title: Adaptive immunity to human coronaviruses is widespread but low in magnitude.
Austin Authors: Tan, Hyon-Xhi;Lee, Wen Shi;Wragg, Kathleen M;Nelson, Christina;Esterbauer, Robyn;Kelly, Hannah G;Amarasena, Thakshila;Jones, Robert M ;Starkey, Graham M ;Wang, Bao Zhong;Yoshino, Osamu ;Tiang, Thomas;Grayson, Michael Lindsay;Opdam, Helen I ;D'Costa, Rohit;Vago, Angela ;Mackay, Laura K;Gordon, Claire L ;Wheatley, Adam K;Kent, Stephen J;Juno, Jennifer A
Affiliation: Surgery
DonateLife Victoria Carlton VIC Australia
Intensive Care Unit The Royal Melbourne Hospital Parkville VIC Australia
Department of Infectious Diseases Austin Health Heidelberg VIC Australia
Melbourne Sexual Health Centre and Department of Infectious Diseases Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australia
Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty institute for Infection and Immunity Melbourne VIC Australia
Australian Research Council Centre for Excellence in Convergent Bio-Nano Science and Technology University of Melbourne Melbourne VIC Australia
DonateLife The Australian Organ and Tissue Authority Carlton VIC Australia
Intensive Care
Issue Date: 17-Mar-2021
metadata.dc.date: 2021-03-17
Publication information: Clinical & Translational Immunology 2021; 10(3): e1264
Abstract: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression. T-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung-draining lymph nodes. Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26136
DOI: 10.1002/cti2.1264
ORCID: 0000-0002-7091-0048
0000-0002-9072-1017
PubMed URL: 33747512
ISSN: 2050-0068
Type: Journal Article
Subjects: CD4 T cell
SARS‐CoV‐2
cTFH
coronavirus
hCoV
lymph node
Appears in Collections:Journal articles

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