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dc.contributor.authorTan, Hyon-Xhi-
dc.contributor.authorLee, Wen Shi-
dc.contributor.authorWragg, Kathleen M-
dc.contributor.authorNelson, Christina-
dc.contributor.authorEsterbauer, Robyn-
dc.contributor.authorKelly, Hannah G-
dc.contributor.authorAmarasena, Thakshila-
dc.contributor.authorJones, Robert M-
dc.contributor.authorStarkey, Graham M-
dc.contributor.authorWang, Bao Zhong-
dc.contributor.authorYoshino, Osamu-
dc.contributor.authorTiang, Thomas-
dc.contributor.authorGrayson, Michael Lindsay-
dc.contributor.authorOpdam, Helen I-
dc.contributor.authorD'Costa, Rohit-
dc.contributor.authorVago, Angela-
dc.contributor.authorMackay, Laura K-
dc.contributor.authorGordon, Claire L-
dc.contributor.authorWheatley, Adam K-
dc.contributor.authorKent, Stephen J-
dc.contributor.authorJuno, Jennifer A-
dc.identifier.citationClinical & Translational Immunology 2021; 10(3): e1264en
dc.description.abstractEndemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression. T-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung-draining lymph nodes. Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.en
dc.subjectCD4 T cellen
dc.subjectlymph nodeen
dc.titleAdaptive immunity to human coronaviruses is widespread but low in magnitude.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical & Translational Immunologyen
dc.identifier.affiliationDonateLife Victoria Carlton VIC Australiaen
dc.identifier.affiliationIntensive Care Unit The Royal Melbourne Hospital Parkville VIC Australiaen
dc.identifier.affiliationDepartment of Infectious Diseases Austin Health Heidelberg VIC Australiaen
dc.identifier.affiliationMelbourne Sexual Health Centre and Department of Infectious Diseases Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australiaen
dc.identifier.affiliationDepartment of Microbiology and Immunology University of Melbourne, at the Peter Doherty institute for Infection and Immunity Melbourne VIC Australiaen
dc.identifier.affiliationAustralian Research Council Centre for Excellence in Convergent Bio-Nano Science and Technology University of Melbourne Melbourne VIC Australiaen
dc.identifier.affiliationDonateLife The Australian Organ and Tissue Authority Carlton VIC Australiaen
dc.identifier.affiliationIntensive Careen
dc.identifier.pubmedid33747512, Claire L
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Liver Transplant Unit- (University of Melbourne)- Surgery- and Hepatology- Liver Transplant Unit- (University of Melbourne)- Care- Liver Transplant Unit- Diseases-
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