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Title: Orexins (hypocretins): the intersection between homeostatic and hedonic feeding.
Austin Authors: Muthmainah, Muthmainah;Gogos, Andrea;Sumithran, Priya ;Brown, Robyn M
Affiliation: The Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville Melbourne, Australia..
The Florey Institute of Neuroscience and Mental Health, Mental Health Research Theme, Parkville Melbourne, Australia..
Medicine (University of Melbourne)
Department of Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia..
Issue Date: 20-Feb-2021 2021
Publication information: Journal of Neurochemistry 2021; online first: 20 February
Abstract: Orexins are hypothalamic neuropeptides originally discovered to play a role in the regulation of feeding behaviour. The broad connections of orexin neurons to mesocorticolimbic circuitry suggests they may play a role in mediating reward related behaviour beyond homeostatic feeding. Here, we review the role of orexin in a variety of eating-related behaviour, with a focus on reward and motivation, and the neural circuits driving these effects. One emerging finding is the involvement of orexins in hedonic and appetitive behaviour toward palatable food, in addition to their role in homeostatic feeding. This review discusses the brain circuitry and possible mechanisms underlying the role of orexins in these behaviours. Overall, there is a marked bias in the literature towards studies involving male subjects. As such, future work needs to be done to involve female subjects. In summary, orexins play an important role in driving motivation for high salient rewards such as highly palatable food and may serve as the intersection between homeostatic and hedonic feeding.
DOI: 10.1111/jnc.15328
ORCID: 0000-0003-4167-3634
PubMed URL: 33608877
Type: Journal Article
Subjects: feeding
food reward
Appears in Collections:Journal articles

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