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Title: NephroCheck® Quality Test.
Austin Authors: Naorungroj, Thummaporn ;Serpa Neto, Ary ;Yanase, Fumitaka ;Bittar, Intissar ;Eastwood, Glenn M ;Bellomo, Rinaldo 
Affiliation: Pathology
Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia
Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Victoria, Australia
Intensive Care
Department of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailand..
Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil
Data Analytics Research and Evaluation (DARE) Centre
Issue Date: 8-Dec-2020 2020-12-08
Publication information: Blood purification 2020; online first: 8 December
Abstract: The acute kidney injury (AKI) risk score helps detect moderate and severe AKI in the next 12-24 h. However, inappropriate urine collection may impact its results. The aim of this study was to evaluate the stability of NephroCheck® after urine storage at different temperatures. The urine sample was centrifuged and split into 3 tubes. One was tested as soon as possible by the laboratory. The other 2 samples were frozen at -20 and -80°C, and the NephroCheck® test was performed 8 weeks later. The mean values of the AKI risk score were 1.19 ± 0.93, 1.15 ± 1.14, and 1.20 ± 1.11 (ng/mL)2/1,000 for fresh urine, -20, and -80°C, respectively (p = 0.70). Spearman's rank correlation for -20 and -80°C versus immediate processing was strong with a rho of 0.82 and 0.98, respectively. The AKI risk score was relatively stable. Urine could be collected without dry ice or liquid nitrogen and kept for up to 8 weeks with either -20 or -80°C freezing with stable NephroCheck® results.
DOI: 10.1159/000511727
PubMed URL: 33291111
Type: Journal Article
Subjects: Acute kidney injury
Acute kidney injury risk score
Critical care
Insulin-like growth factor binding protein-7
Tissue inhibitor of metalloproteinases-2
Appears in Collections:Journal articles

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