Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25035
Title: Differential associations of hypoxia, sleep fragmentation and depressive symptoms with cognitive dysfunction in obstructive sleep apnoea.
Austin Authors: Alomri, Ridwan M;Kennedy, Gerard A ;Wali, Siraj Omar;Ahejaili, Faris;Robinson, Stephen R
Affiliation: School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia
University of Jeddah, College of Social Sciences, Department of Psychology, Jeddah, Saudi Arabia
Institute for Breathing and Sleep
School of Science, Psychology and Sport, Federation University, Ballarat, Victoria, Australia
Sleep Medicine and Research Centre, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Issue Date: Apr-2021
metadata.dc.date: 2020-10-12
Publication information: Sleep 2021; 44(4): zsaa213
Abstract: Obstructive sleep apnoea (OSA) is characterized by recurrent episodes of partial or complete cessation of breathing during sleep and increased effort to breathe. This study examined patients who underwent overnight polysomnographic studies in a major sleep laboratory in Saudi Arabia. The study aimed to determine the extent to which intermittent hypoxia, sleep disruption and depression are independently associated with cognitive impairments in OSA. In the sample of 90 participants, 14 had no OSA, 30 mild OSA, 23 moderate OSA and 23 severe OSA. The findings revealed that hypoxia and sleep fragmentation are independently associated with impairments of sustained attention and reaction time. Sleep fragmentation but not hypoxia, was independently associated with impairments in visuospatial deficits. Depressive symptoms were independently associated with impairments in the domains of sustained attention, reaction time, visuospatial ability, and semantic and episodic autobiographical memories. Since the depressive symptoms are independent of hypoxia and sleep fragmentation, effective reversal of cognitive impairment in OSA may require treatment interventions that target each of these factors.
URI: https://ahro.austin.org.au/austinjspui/handle/1/25035
DOI: 10.1093/sleep/zsaa213
PubMed URL: 33045082
Type: Journal Article
Subjects: Sustained attention
autobiographical memory
reaction time
visuospatial ability
vitamin D
Appears in Collections:Journal articles

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