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Title: Future directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy.
Austin Authors: Teh, Jiasian ;O'Connor, Ellen ;O'Brien, Jonathon;Lim, Wei Mou;Taylor, Michael;Heriot, Alexander;Ramsay, Robert;Lawrentschuk, Nathan
Affiliation: EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Victoria 3121, Australia
Division of Cancer Surgery, Peter MacCallum Centre, Melbourne, Victoria 3000, Australia
Sir Peter MacCallum Dept. of Oncology, University of Melbourne, Melbourne, Victoria 3000, Australia
Department of Surgery, University of Melbourne & Royal Melbourne Hospital, Department of Urology, Melbourne, Victoria 3000, Australia
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: Oct-2020
Date: 2020-07-26
Publication information: Future Oncology 2020; 16(29):2357-2369
Abstract: Penile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity, there have been few substantial advances in our understanding of the molecular and genomic drivers of penile SCC, especially for patients with relapsed or advanced disease. In this review, we discuss the molecular and genomic landscape of penile SCC, clinical trials in progress and implications for novel therapeutic targets. Future work should focus on preclinical models to provide a platform for investigation and validation of new molecular pathways for testing of therapeutics.
DOI: 10.2217/fon-2020-0434
ORCID: 0000-0002-7882-5155
Journal: Future Oncology
PubMed URL: 32713198
Type: Journal Article
Subjects: immunotherapy
penile cancer
solid tumor
squamous cell carcinoma
Appears in Collections:Journal articles

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