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|Title:||Future directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy.|
|Authors:||Teh, Jiasian;O'Connor, Ellen;O'Brien, Jonathon;Lim, Wei Mou;Taylor, Michael;Heriot, Alexander;Ramsay, Robert;Lawrentschuk, Nathan|
|Affiliation:||EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Victoria 3121, Australia|
Division of Cancer Surgery, Peter MacCallum Centre, Melbourne, Victoria 3000, Australia
Sir Peter MacCallum Dept. of Oncology, University of Melbourne, Melbourne, Victoria 3000, Australia
Department of Surgery, University of Melbourne & Royal Melbourne Hospital, Department of Urology, Melbourne, Victoria 3000, Australia
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
|Citation:||Future oncology (London, England) 2020; online first: 26 July|
|Abstract:||Penile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity, there have been few substantial advances in our understanding of the molecular and genomic drivers of penile SCC, especially for patients with relapsed or advanced disease. In this review, we discuss the molecular and genomic landscape of penile SCC, clinical trials in progress and implications for novel therapeutic targets. Future work should focus on preclinical models to provide a platform for investigation and validation of new molecular pathways for testing of therapeutics.|
squamous cell carcinoma
|Appears in Collections:||Journal articles|
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